Vascular Calcification as a Novel Risk Factor for Kidney Function Deterioration in the Nonelderly

Autor: Eun Young Lee, Hyo-Wook Gil, Eun-Jung Rhee, Samel Park, Nam Hun Heo, Nam-Jun Cho
Rok vydání: 2021
Předmět:
Adult
Male
medicine.medical_specialty
2019-20 coronavirus outbreak
Coronavirus disease 2019 (COVID-19)
Epidemiology
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
030232 urology & nephrology
Renal function
Coronary Artery Disease
030204 cardiovascular system & hematology
Kidney
Severity of Illness Index
Young Adult
03 medical and health sciences
0302 clinical medicine
Risk Factors
Predictive Value of Tests
Cardiovascular Disease
Internal medicine
Republic of Korea
medicine
Humans
Renal Insufficiency
Chronic
Risk factor
Vascular Calcification
Vascular calcification
coronary artery calcium
Original Research
Aged
Proportional Hazards Models
Retrospective Studies
Kidney in Cardiovascular Disease
business.industry
renal function
Middle Aged
medicine.disease
Coronary artery calcium
risk factor
Disease Progression
Linear Models
Cardiology
Female
Tomography
X-Ray Computed
Cardiology and Cardiovascular Medicine
business
chronic kidney disease
Glomerular Filtration Rate
Kidney disease
Zdroj: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
ISSN: 2047-9980
Popis: Background The relationship between vascular calcification and chronic kidney disease is well known. However, whether vascular calcification affects renal function deterioration remains unclear. We investigated whether kidney function deteriorated more rapidly in individuals with higher vascular calcification indicated by the coronary artery calcium score (CACS). Methods and Results Individuals with a normal estimated glomerular filtration rate (>60 mL/min per 1.73 m 2 ) who underwent cardiac computed tomography in our institution (a tertiary teaching hospital in Cheonan, Korea) from January 2010 to July 2012 were retrospectively reviewed. All participants were aged 20 to 65 years. Among 739 patients, 447, 175, and 117 had CACSs of 0, 1 to 99, and ≥100 units, respectively. The participants were followed for 7.8 (interquartile range, 5.5–8.8) years. The adjusted annual estimated glomerular filtration rates declined more rapidly in patients in the CACS ≥100 group compared with those in the CACS 0 group (adjusted‐β, −0.40; 95% CI, −0.80 to −0.03) when estimated using a linear mixed model. The adjusted hazard ratio in the CACS ≥100 group for Kidney Disease: Improving Global Outcomes criteria (a drop in estimated glomerular filtration rate category accompanied by a 25% or greater drop in estimated glomerular filtration rate) was 2.52 (1.13–5.61). After propensity score matching, more prevalent renal outcomes (13.2%) were observed in patients with a CACS of ≥100 compared with those with a CACS of 0 (1.9%), with statistical significance ( P =0.004). Conclusions Our results showed that renal function declined more rapidly in patients with higher CACSs, suggesting that vascular calcification might be associated with chronic kidney disease progression.
Databáze: OpenAIRE
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