Can we justify spermatid microinjection for severe male factor infertility?
| Autor: | Simon Fishel, Irfan Aslam, H. McDermott, L Garratt, Alison Campbell, S Green, Ken Dowell, Simon Thornton |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
Infertility endocrine system medicine.medical_specialty Microinjections media_common.quotation_subject Context (language use) Fertility Fertilization in Vitro Biology Bioinformatics Male infertility Birth rate medicine Humans Infertility Male media_common Gynecology Clinical Trials as Topic Pregnancy Spermatid urogenital system Obstetrics and Gynecology medicine.disease Spermatids Treatment Outcome medicine.anatomical_structure Reproductive Medicine Female Live birth |
| Zdroj: | Human Reproduction Update. 4:213-222 |
| ISSN: | 1460-2369 1355-4786 |
| DOI: | 10.1093/humupd/4.3.213 |
| Popis: | During 1995 and 1996 the first spermatid pregnancies were announced with both round spermatid (ROSI) and elongated spermatid (ELSI) injections. These publications were flanked by live births from ROSI in a number of animal species, with resulting offspring appearing normal, healthy and fertile. However, the live births in humans heralded a scientific and ethical debate on the clinical use of this technology; and in a number of countries nationwide moratoria prohibiting spermatid microinjection were enjoined. Concerns surrounded the biological condition of spermatids and clinical implications of utilizing an immature spermatozoon for conception. Nevertheless, case reports and a few scientific studies on human spermatid conception have been published in recent years, and further polemic on testicular histopathology and prognosis has ensued. This paper reviews the current arguments on the clinical use of ROSI and ELSI, and evaluates the biology of the main contributory components of a spermatozoon to the subsequent embryo, namely the genetic material, the microtubular organizing complex and the putative oocyte activating factor. We also consider the relevant testicular histopathology and likely outcome in the context of the current birth rate from ROSI and ICSI. We conclude by considering the way forward for infertile men who require this technology to become genetic fathers, and whether the time is now appropriate to consider clinical trials. |
| Databáze: | OpenAIRE |
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