Atacamycins A–C, 22-membered antitumor macrolactones produced by Streptomyces sp. C38
| Autor: | Alan T. Bull, Andreas Kulik, Michael Goodfellow, Hans-Peter Fiedler, Juan A. Asenjo, Soleiman E. Helaly, Jutta Wiese, Jonny Nachtigall, Johannes F. Imhoff, Armin Maier, Roderich D. Süssmuth |
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| Rok vydání: | 2011 |
| Předmět: |
Spectrometry
Mass Electrospray Ionization Stereochemistry Electrospray ionization Antineoplastic Agents Microbial Sensitivity Tests Biology Streptomyces Cell Line Tumor Spectroscopy Fourier Transform Infrared Drug Discovery Humans Chile Enzyme Inhibitors Nuclear Magnetic Resonance Biomolecular Soil Microbiology Mycelium Pharmacology chemistry.chemical_classification Molecular Structure Strain (chemistry) Phosphodiesterase biology.organism_classification Cyclic Nucleotide Phosphodiesterases Type 4 Enzyme Biochemistry chemistry Cell culture Polyketides Desert Climate Drug Screening Assays Antitumor Soil microbiology |
| Zdroj: | The Journal of Antibiotics. 64:775-780 |
| ISSN: | 1881-1469 0021-8820 |
| DOI: | 10.1038/ja.2011.96 |
| Popis: | Three new 22-membered macrolactone antibiotics, atacamycins A-C, were produced by Streptomyces sp. C38, a strain isolated from a hyper-arid soil collected from the Atacama Desert in the north of Chile. The metabolites were discovered in our HPLC-diode array screening and isolated from the mycelium by extraction and chromatographic purification steps. The structures were determined by mass spectrometry and NMR experiments. Atacamycins A, B and C exhibited moderate inhibitory activities against the enzyme phosphodiesterase (PDE-4B2), whereas atacamycin A showed a moderate antiproliferative activity against adeno carcinoma and breast carcinoma cells. |
| Databáze: | OpenAIRE |
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