Efficacy of Emodepside plus Toltrazuril Suspension (Procox® Oral Suspension for Dogs) against Prepatent and Patent Infection with Isospora canis and Isospora ohioensis-Complex in Dogs
| Autor: | Klemens Krieger, Nadine Gasda, Gertraut Altreuther, Annette Schimmel, Terry Settje, Douglas Hutchens, Iris Schroeder, Anja Joachim |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Diarrhea
Veterinary medicine Isospora canis Excretion chemistry.chemical_compound Dogs Coccidia Double-Blind Method Depsipeptides parasitic diseases Toltrazuril medicine Animals Dog Diseases Parasite Egg Count Isospora General Veterinary biology Triazines General Medicine Isosporiasis biology.organism_classification Drug Combinations Infectious Diseases Canis chemistry Insect Science Coccidiostats Drug Evaluation Parasitology Isospora ohioensis Emodepside medicine.drug |
| Zdroj: | Parasitology Research. 109:9-20 |
| ISSN: | 1432-1955 0932-0113 |
| DOI: | 10.1007/s00436-011-2398-0 |
| Popis: | Three randomised, blinded and placebo-controlled laboratory studies were conducted to evaluate the efficacy of emodepside plus toltrazuril suspension (Procox(®) suspension for dogs) against Isospora canis and Isospora ohioensis-complex. Unweaned puppies were experimentally infected with sporulated oocysts of I. canis and/or I. ohioensis-complex. In each study, one group was treated during prepatency (2 or 4 days post infection) while dogs in the second group were treated individually after the onset of oocyst excretion of the respective coccidia species. The dogs were treated with the minimum therapeutic dose of 0.45 mg emodepside and 9 mg toltrazuril per kg body weight. Daily faecal oocyst counts from both groups were compared to placebotreated control groups to determine efficacy.Dogs treated during prepatent I. canis or I. ohioensis-complex infection showed significantly lower oocyst counts for up to 12 days compared to the control group. Oocyst counts were reduced by 90.2 - 100 % while the control groups continued to exhibit an adequate infection, except for one study where efficacy against prepatent I. canis infection faded 13 days after treatment. Following treatment of patent I. canis or I. ohioensis-complex infections, significantly lowered oocyst counts were observed for up to 9 days compared to the control group. Faecal oocyst counts were reduced by 91.5 - 100 %. In all three studies the number of days with diarrhoea was significantly lower when dogs were treated during prepatent Isospora spp. infection compared to the control groups. No adverse drug reactions were observed during the studies. In conclusion, the studies demonstrated that emodepside plus toltrazuril suspension is an efficient coccidiocide for dogs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink