Alcohol use, physical activity, and muscle strength moderate the relationship between body composition and frailty risk among people living with HIV

Autor: Danielle E. Levitt, Liz Simon, Hui‐Yi Lin, Robert W. Siggins, Tekeda F. Ferguson, Patricia E. Molina, David A. Welsh
Rok vydání: 2022
Předmět:
Zdroj: Alcoholism: Clinical and Experimental Research. 46:2041-2053
ISSN: 1530-0277
0145-6008
DOI: 10.1111/acer.14941
Popis: Antiretroviral therapy has improved life expectancy among people living with HIV (PLWH). Despite increased longevity, PLWH are at increased risk of age-related comorbidities, including frailty. We examined the relationship between body composition and frailty among PLWH, and moderation of this relationship by substance use, physical activity (PA), and physical function.Participants (n = 341; 71% male, 48 ± 10 years, body mass index (BMI) = 27.3 ± 7.0 kg/mMultivariable linear regression adjusted for age, sex, and race showed that higher fat-free mass index (FFMI), body fat (%), waist-to-hip ratio, and body mass index (BMI) ≥ 25.0 kg/mOur findings indicate that body composition has significant modulatory effects on frailty risk in PLWH, where obesity increases the risk of frailty and greater muscle mass may be protective, even in individuals who use alcohol. These results highlight the importance of considering body composition, physical activity, and physical function in assessing frailty risk in PLWH, particularly among individuals who use alcohol. Moreover, they support the implementation of physical activity interventions to ameliorate the risk of frailty in aging PLWH.
Databáze: OpenAIRE
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