Comparative Analysis of MiB1 and p53 Expression in Human Bladder Tumors and Their Correlation with Cancer Progression
| Autor: | Ghislain Bochereau, Françoise Buzelin, Christian Pfister, Olivier Bouchot, Jean Marie Buzelin, Christophe Casse |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Pathology
medicine.medical_specialty Urology Human bladder Resection Correlation Gene expression Biomarkers Tumor Carcinoma medicine Humans P53 expression Ploidies Urinary bladder business.industry Antibodies Monoclonal Cancer DNA Neoplasm Prognosis medicine.disease Immunohistochemistry Ki-67 Antigen medicine.anatomical_structure Urinary Bladder Neoplasms Cancer research Tumor Suppressor Protein p53 business |
| Zdroj: | European Urology. 33:278-284 |
| ISSN: | 1421-993X 0302-2838 |
| DOI: | 10.1159/000019580 |
| Popis: | Expression of p53 and MiB1, markers of tumor proliferation, was evaluated in human bladder tumors, and correlated with ploidy and cancer progression in 83 consecutive patients. Transurethral resection of a newly diagnosed bladder tumor was performed in 73 cases, and systematic bladder biopsies were performed in 10 cases after bacillus Calmette-Guerin (BCG) treatment. p53 and MiB1 expression were performed by an immunohistochemical technique and the ploidy was determined on a frozen fragment of the tumor. p53 expression was correlated in relation to grade, stage and combination of grade and stage. MiB1 expression was correlated with cytological grade, and a significant difference was demonstrated between pT0 and pTa, pTa, and pT1, pTa and pT2 tumors but not between pT1 andor = pT2 tumors. A discordance was observed for the comparison of p53 and MiB1 values, stage by stage, suggesting that these two techniques are independent of each other. A larger proportion of aneuploid tumors were positive for p53 and MiB1 (64.8 vs. 86.5%, respectively), but p53 and MiB1 immunostaining were not better indicators than ploidy alone to predict cancer progression. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|