Unveiling the pathogenesis of perineural invasion from the perspective of neuroactive molecules
| Autor: | Crysvane Araújo, Muhammad Sharjeel, Maira Galdino da Rocha Pitta, Moacyr Jesus Barreto de Mello Rego, Michelly Cristiny Pereira, Renata Virgínia Calvancanti Santos, Maria Clara Pinheiro Duarte Sampaio, Michelle Melgarejo da Rosa |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Perineural invasion Malignancy Biochemistry Metastasis Pathogenesis 03 medical and health sciences 0302 clinical medicine Peripheral Nervous System Neoplasms medicine Tumor Microenvironment Animals Humans Neoplasm Invasiveness Nerve Growth Factors Peripheral Nerves Pharmacology Neurotransmitter Agents biology business.industry Cancer medicine.disease Crosstalk (biology) 030104 developmental biology 030220 oncology & carcinogenesis Cancer cell biology.protein business Neuroscience Neurotrophin |
| Zdroj: | Biochemical pharmacology. 188 |
| ISSN: | 1873-2968 |
| Popis: | Perineural invasion (PNI) is characterized by an encounter between the cancer cells and neuronal fibers and holds an extremely poor prognosis for malignant tumors. The exact molecular mechanism behind PNI yet remains to be explored. However, it is worth-noting that an involvement of the neuroactive molecules plays a major part in this process. A complex signaling network comprising the interplay between immunological cascades and neurogenic molecules such as tumor-derived neurotrophins, neuromodulators, and growth factors constitutes an active microenvironment for PNI associated with malignancy. The present review aims at discussing the following points in relation to PNI: a) Communication between PNI and neuroplasticity mechanisms can explain the pathophysiology of poor, short and long-term outcomes in cancer patients; b) Neuroactive molecules can significantly alter the neurons and cancer cells so as to sustain PNI progression; c) Finally, careful manipulation of neurogenic pathways and/or their crosstalk with the immunological molecules implicated in PNI could provide a potential breakthrough in cancer therapeutics. |
| Databáze: | OpenAIRE |
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