Low-dose gadobenate dimeglumine-enhanced MRI of the kidney for the differential diagnosis of localized renal lesions
| Autor: | Guenther Schneider, Peter Fries, Miles A. Kirchin, Arno Buecker, Thorsten Probst, Jonas Stroeder |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Lymphoma Contrast Media Renal MRI Kidney Diagnosis Differential Meglumine Renal cell carcinoma Gadobenate dimeglumine medicine Organometallic Compounds Humans Radiology Nuclear Medicine and imaging False Positive Reactions Child Carcinoma Renal Cell False Negative Reactions Neuroradiology Aged Abdominal Radiology medicine.diagnostic_test business.industry Ultrasound Magnetic resonance imaging Interventional radiology General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging Kidney Neoplasms medicine.anatomical_structure Radiology Nuclear Medicine and imaging Female Radiology Differential diagnosis business Artifacts medicine.drug |
| Zdroj: | La Radiologia Medica |
| ISSN: | 0033-8362 |
| DOI: | 10.1007/s11547-015-0548-7 |
| Popis: | Objective To evaluate low-dose gadobenate dimeglumine-enhanced MRI for the differential diagnosis of malignant renal tumors. Methods Sixty-two consecutive patients with unclear diagnosis at MDCT/ultrasound underwent dynamic CE-MRI of the kidneys with 0.05 mmol/kg gadobenate dimeglumine. Retrospective image evaluation was performed by two blinded readers. Lesion diagnosis at CE-MRI was correlated with findings from histology following tumor resection or from imaging follow-up after at least 1 year. Assessments were performed of diagnostic quality and level of diagnostic information. Results Thirty-nine (63 %) patients were correctly diagnosed with malignant lesions (36 with RCC, 2 with renal metastases, 1 with lymphoma) while 14 (22.6 %) patients were correctly diagnosed with benign (n = 12) or no (n = 2) lesions. Eight patients were considered false positive (5 with oncocytoma, 3 with atypical AML) and 1 patient false negative (atypical RCC). The sensitivity, specificity, accuracy, PPV, and NPV for the diagnosis of malignant renal lesions were 97.5 % (39/40), 63.6 % (14/22), 85.5 % (53/62), 83.0 % (39/47), and 93.3 % (14/15), respectively. Images were excellent in 60 and good in 2 patients. Minimal artifacts that did not compromise diagnosis were noted in 4/62 patients. Conclusion Low-dose gadobenate dimeglumine-enhanced MRI is effective for the differential diagnosis of malignant renal tumors. |
| Databáze: | OpenAIRE |
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