Intramolecular folding in three tandem guanine repeats of human telomeric DNA
| Autor: | Hanbin Mao, Yuta Sannohe, Hiroshi Sugiyama, Deepak Koirala, Tomoko Mashimo, Zhongbo Yu |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Circular dichroism
Guanine Stereochemistry Sequence (biology) Molecular Dynamics Simulation G-quadruplex Catalysis chemistry.chemical_compound Materials Chemistry Humans A-DNA Tandem Chemistry Circular Dichroism Metals and Alloys Hydrogen Bonding General Chemistry DNA Telomere Surfaces Coatings and Films Electronic Optical and Magnetic Materials Folding (chemistry) G-Quadruplexes Biochemistry Intramolecular force Ceramics and Composites Nucleic Acid Conformation |
| Zdroj: | Chemical communications (Cambridge, England). 48(14) |
| ISSN: | 1364-548X |
| Popis: | Intramolecular folding in three tandem guanine repeats of human telomeric DNA has been investigated using optical-tweezers, MD simulation and circular dichroism. A mechanically and thermodynamically stable species in this sequence shows a structure consistent with a triplex conformation. A similar species has also been observed to coexist with a G-quadruplex in a DNA sequence with four tandem guanine repeats. |
| Databáze: | OpenAIRE |
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