Renal Sympathetic Denervation for the Treatment of Systemic Hypertension
| Autor: | William H. Frishman, Gordon M. Burke, Domenic A. Sica |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Sympathetic Nervous System business.industry Efferent Renal function Blood Pressure General Medicine Kidney Left ventricular hypertrophy medicine.disease Clinical trial Autonomic nervous system Catheter Blood pressure Renal sympathetic denervation Internal medicine Hypertension Catheter Ablation Cardiology Humans Medicine Treatment Failure Sympathectomy Cardiology and Cardiovascular Medicine business |
| Zdroj: | Cardiology in Review. 20:274-278 |
| ISSN: | 1061-5377 |
| Popis: | Systemic hypertension is a common cardiovascular problem that often cannot be fully treated with existing nonpharmacologic and pharmacologic measures. A catheter-based strategy which denervates the renal afferent and efferent autonomic nervous system has been developed for the treatment of drug-resistant hypertension. In early clinical trials, this procedure was shown to be both feasible and safe in reducing blood pressure in patients with uncontrolled hypertension receiving treatment with a minimum of 3 antihypertensive drugs. In addition, this procedure has been associated with decreased renin secretion, preservation of renal function, improved glucose tolerance, and a reduction in left ventricular hypertrophy. The long-term effects of this procedure (beyond 3 years) still need to be determined. A large 530-patient sham-controlled trial is now in progress. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|