Development of a magnetic system for the treatment of Helicobacter pylori infections
| Autor: | José Humberto de Araújo, Aldo Cunha Medeiros, Bárbara L. Francelino, Artur da Silva Carriço, E. Socrates T. Egito, Érica L. Silva, Juliana Fernandes De Carvalho, Thales R. F. Pontes, Elquio Eleamen Oliveira |
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| Rok vydání: | 2009 |
| Předmět: |
Materials science
Helicobacter pylori Sprayer Coprecipitation Superparamagnetic particle Nanotechnology Amoxicillin Condensed Matter Physics Electronic Optical and Magnetic Materials chemistry.chemical_compound chemistry Spray drying Magnetite microparticle medicine Magnetic nanoparticles Pray drying coating Magnetic vectorization Microparticle Superparamagnetism Nuclear chemistry Magnetite medicine.drug |
| Zdroj: | Repositório Institucional da UFRN Universidade Federal do Rio Grande do Norte (UFRN) instacron:UFRN |
| ISSN: | 0304-8853 |
| DOI: | 10.1016/j.jmmm.2009.02.087 |
| Popis: | We report a study to develop a magnetic system for local delivery of amoxicillin. Magnetite microparticles produced by coprecipitation were coated with a solution of amoxicillin and Eudragit ® S100 by spray drying. Scanning electron microscopy, optical microscopy, X-ray powder diffraction and vibrating sample magnetometry revealed that the particles were superparamagnetic, with an average diameter of 17.2 μm, and an initial susceptibility controllable by the magnetite content in the suspension feeding the sprayer. Our results suggest a possible way to treat Helicobacter pylori infections, using an oral drug delivery system, and open prospects to coat magnetic microparticles by spray drying for biomedical applications. |
| Databáze: | OpenAIRE |
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