Regional myocardial perfusion imaging in predicting vessel-related outcome: interplay between the perfusion results and angiographic findings

Autor: Teresa Mannarino, Adriana D’Antonio, Roberta Assante, Emilia Zampella, Valeria Gaudieri, Pietro Buongiorno, Valeria Cantoni, Roberta Green, Carmela Nappi, Emanuele Criscuolo, Roberto Bologna, Mario Petretta, Piotr Slomka, Alberto Cuocolo, Wanda Acampa
Přispěvatelé: Mannarino, Teresa, D’Antonio, Adriana, Assante, Roberta, Zampella, Emilia, Gaudieri, Valeria, Buongiorno, Pietro, Cantoni, Valeria, Green, Roberta, Nappi, Carmela, Criscuolo, Emanuele, Bologna, Roberto, Petretta, Mario, Slomka, Piotr, Cuocolo, Alberto, Acampa, Wanda
Rok vydání: 2022
Předmět:
Zdroj: European Journal of Nuclear Medicine and Molecular Imaging. 50:160-167
ISSN: 1619-7089
1619-7070
DOI: 10.1007/s00259-022-05948-w
Popis: Background Despite myocardial perfusion imaging (MPI) by cadmium-zinc-telluride (CZT) single-photon emission computed tomography (SPECT) camera is largely used in the diagnosis and risk stratification of patients with suspected or known coronary artery disease (CAD), no data are available on the prognostic value of a regional MPI evaluation. We evaluated the prognostic value of regional MPI by the CZT camera in predicting clinical outcomes at the vessel level in patients with available angiographic data. Methods and results Five hundred and forty-one subjects with suspected or known CAD referred to 99mTc-sestamibi gated CZT-SPECT cardiac imaging and with available angiographic data were studied. Both regional total perfusion deficit (TPD) and ischemic TPD (ITPD) were calculated separately for each vascular territory (left anterior descending, left circumflex, and right coronary artery). The outcome end points were cardiac death, target vessel-related myocardial infarction, or late coronary revascularization. The prevalence of CAD ≥ 50%, regional stress TPD, and regional ITPD was significantly higher in vessels with events as compared to those without (both P < 0.001). The receiver operating characteristics area under the curve for regional ITPD for the identification of vessel-related events was 0.81 (95% confidence interval 0.75–0.86). An ITPD value of 2.0% provided the best trade-off for identifying the vessel-related event. At multivariable analysis, both CAD ≥ 50% and ITPD ≥ 2.0% resulted in independent predictors of events. Conclusions Regional myocardial perfusion assessed by the CZT camera demonstrated good reliability in predicting vessel-related events in patients with suspected or known CAD.
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje