A Telemetric light delivery system for metronomic photodynamic therapy (mPDT) in rats
| Autor: | Eduardo Margallo Balbas, Patrick J. French, Angelique van der Ploeg-van den Heuvel, Henricus J. C. M. Sterenborg, Floor van Zaane, Dominic J. Robinson, Henriëtte S. de Bruijn, Gregory Pandraud, Devendiran Subbaiyan |
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| Přispěvatelé: | Radiotherapy, Neurology |
| Rok vydání: | 2010 |
| Předmět: |
Male
Time Factors Light medicine.medical_treatment Solid-state General Physics and Astronomy Biocompatible Materials Nanotechnology Photodynamic therapy Light delivery General Biochemistry Genetics and Molecular Biology In vivo Materials Testing medicine Animals Telemetry General Materials Science Rats Wistar Brain Neoplasms business.industry General Engineering Equipment Design General Chemistry medicine.disease Rats Equipment Failure Analysis Disease Models Animal Photochemotherapy Feasibility Studies Equipment Failure Implant Extended time Glioblastoma business After treatment Biomedical engineering |
| Zdroj: | Journal of Biophotonics, 3(5-6), 347-355. Wiley-VCH |
| ISSN: | 1864-063X |
| DOI: | 10.1002/jbio.200900098 |
| Popis: | Light delivery and monitoring during photodynamic therapy (PDT) is often limited by the need for a physical link between the light source, detectors and the treatment volume. This paper reports on the first in vivo experiments performed with a fully implantable telemetric system, designed for a rat glioblastoma model. In this system, light delivery is performed using a solid state optode containing 2 LEDs, and 4 photodiodes which will be used to monitor light delivery in future experiments. Powering and communication is achieved by means of an inductive link. The implant may remain in the animal for extended time periods, making it particularly interesting for performing metronomic PDT. In this paper, we demonstrate the feasibility of in vivo light delivery and biocompatibility of the device.. Activation of the inductive link as well as illumination of the brain by the LED did not influence animal behavior during or after treatment. We show that the implant can remain in the animal for two weeks without causing serious biological reactions. [GRAPHICS] The implant for telemetric light delivery in the rat brain. |
| Databáze: | OpenAIRE |
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