Diffusion-Weighted Magnetic Resonance Imaging for Predicting and Detecting the Early Response to Chemoradiotherapy of Advanced Esophageal Squamous Cell Carcinoma
| Autor: | Hisahiro Matsubara, Tsuguaki Kono, Shunsuke Imanishi, Kiyohiko Shuto, Tomoyoshi Aoyagi, Hiroshige Saito |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Esophageal Neoplasms medicine.medical_treatment Esophageal squamous cell carcinoma Nuclear magnetic resonance Predictive Value of Tests Antineoplastic Combined Chemotherapy Protocols Carcinoma medicine Humans Effective diffusion coefficient Neoplasm Invasiveness Aged Neoplasm Staging Retrospective Studies medicine.diagnostic_test business.industry Gastroenterology Magnetic resonance imaging Chemoradiotherapy Adjuvant Esophageal cancer equipment and supplies medicine.disease Diffusion-Weighted Magnetic Resonance Imaging Esophagectomy body regions Diffusion Magnetic Resonance Imaging Treatment Outcome Carcinoma Squamous Cell Female Surgery Dose Fractionation Radiation Fluorouracil Radiology Cisplatin business human activities Chemoradiotherapy |
| Zdroj: | Digestive Surgery. 30:240-248 |
| ISSN: | 1421-9883 0253-4886 |
| DOI: | 10.1159/000351435 |
| Popis: | Background: The aim of this study was to investigate the utility of the apparent diffusion coefficient (ADC) value in diffusion-weighted magnetic resonance imaging (DWMRI) for prediction and early detection of treatment response in advanced esophageal squamous cell carcinoma. Method: DWMRI was performed in 27 patients with primary cT4 esophageal carcinoma that were undergoing chemoradiotherapy before treatment and after 20 and 40 Gy. We calculated tumor ADCs and association of the treatment effect between responders and nonresponders. Results: The ADC at the time of 20 Gy was significantly higher in responders compared to nonresponders (1.13 vs. 0.93; p = 0.005). The ADC cut-off value was set at 1.00 × 10-3 mm2/s and the ADC predicted the responders with a sensitivity, positive predictive value and accuracy of 79, 73 and 74%, respectively. The increased rate of the ADC at the time of 20 Gy (ΔADC20) was also significantly higher in responders compared to nonresponders (35.4 vs. 1.5%; p = 0.0007). An ADC cut-off value for ΔADC20 of 15% predicted the responders with a sensitivity, positive predictive value and accuracy of 71, 100 and 85%, respectively. Conclusion: The ADC values predicted the prognosis of patients with advanced esophageal squamous cell carcinoma as well as the treatment response. |
| Databáze: | OpenAIRE |
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