Underestimation of the coexistence of iron deficiencies and thalassemia minors: a single institution experience in Taiwan
| Autor: | Yung-Chuan Sung, Hsiu-Lin Chang, Chung-King Lin, Ling-Ping Chen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Delayed Diagnosis Hemoglobin electrophoresis Adolescent Thalassemia Population Taiwan Comorbidity Sensitivity and Specificity Iron studies Young Adult medicine Humans Child education Thalassemia minor Aged Retrospective Studies Medicine(all) Aged 80 and over education.field_of_study lcsh:R5-920 Anemia Iron-Deficiency medicine.diagnostic_test biology business.industry Iron deficiency beta-Thalassemia Beta thalassemia General Medicine Automated hematology analyzer Middle Aged medicine.disease Electrophoreses Ferritin Child Preschool Serum iron biology.protein Female business lcsh:Medicine (General) |
| Zdroj: | Kaohsiung Journal of Medical Sciences, Vol 30, Iss 8, Pp 409-414 (2014) |
| Popis: | Some physicians neglect the possible coexistence of an iron deficiency with a thalassemia minor and do not treat the iron deficiency accordingly. This motivated us to conduct this study. We retrospectively reviewed the records of 3892 patients who visited our clinics and had hemoglobin (Hb) electrophoreses performed in our hematologic laboratory from August 1, 2007 to December 31, 2012. The thalassemia minors were identified by characteristic complete blood count (CBC) parameters obtained from an autoanalyzer and Hb electrophoresis, and some cases were confirmed with molecular tests. Then, we checked iron studies [ferritin and/or serum iron with total iron-binding capacity (TIBC)] to determine the coexistence of an iron deficiency with a thalassemia minor and a response to iron, if such treatments were given. We found 792 cases with thalassemia minors, and excluded those without iron studies, with 661 cases as our sample. A total of 202/661 cases (31%) also had iron deficiencies. They had lower red blood cell (RBC) counts, Hb, and ferritin levels as compared to those thalassemia minor cases without coexistence of iron deficiencies. We concluded that the thalassemia minor patients did not have iron overload complications in our population. On the contrary, iron deficiencies commonly coexist in the clinical visits. We propose that if Hb |
| Databáze: | OpenAIRE |
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