Actions of sex hormones on the brain
| Autor: | Rüdiger Ghraf, Markus Banger, Christoph Hiemke, Ralf Kohsik, Michael Hundt |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Ovariectomy Norepinephrine Sex hormone-binding globulin Pregnancy Internal medicine medicine Animals Testosterone Gonadal Steroid Hormones Biological Psychiatry Pharmacology Neurotransmitter Agents Estradiol biology Brain Estrogens Rats Inbred Strains Sex hormone receptor Preoptic Area Rats Preoptic area Endocrinology Animals Newborn Sex steroid biology.protein Female Orchiectomy Defeminization medicine.drug Hormone |
| Zdroj: | Progress in Neuro-Psychopharmacology and Biological Psychiatry. 16:377-388 |
| ISSN: | 0278-5846 |
| DOI: | 10.1016/0278-5846(92)90089-w |
| Popis: | 1. The brain is a target for sex steroid hormones. As a result of sex hormone actions on the brain various behavioral changes are observed in animal and man. This paper gives a brief overview over the multiple central nervous functions that are under modulatory control of sexual hormones and describes the complex sex steroid actions on the brain by giving an example for "activating" and "organizing" effects of estrogens on noradrenergic neurons in the brain of rats. 2. Estradiol-17 beta induced sex specific alterations in the turnover of noradrenaline in the preoptic area and mediobasal hypothalamus showing "female" or "male" responses. 3. Neonatal manipulations of female rat pups by testosterone, estradiol-17 beta or 4-hydroxyestradiol-17 beta defeminized the "female" response of the noradrenaline turnover in the preoptic area. 4. Defeminization was not observed when neonatal females received the non aromatizable sex steroid dihydrotestosterone. 5. Activating and organizing effects of sex steroids on animal brain as shown here for noradrenergic neurons are discussed in relation to the regulation of behavior in man. Special regard is given to psychic disorders that might be associated with abnormalities in the production or metabolism of or the response to gonadal hormones. |
| Databáze: | OpenAIRE |
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