Humanin peptides block calcium influx of rat hippocampal neurons by altering fibrogenesis of Abeta(1-40)
| Autor: | Baihe Hu, Yinlin Sha, Ping Zou, Songqing Nie, Yanan Ding |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Physiology
Molecular Sequence Data chemistry.chemical_element Hippocampus Peptide Calcium Hippocampal formation Biochemistry Cellular and Molecular Neuroscience Endocrinology medicine Animals Amino Acid Sequence Humanin chemistry.chemical_classification Neurons Amyloid beta-Peptides Ion Transport Receptor Aggregation Neurotoxicity Intracellular Signaling Peptides and Proteins Proteins medicine.disease Peptide Fragments Cell biology Rats medicine.anatomical_structure Neuroprotective Agents chemistry Apoptosis Neuron Peptides |
| Zdroj: | Peptides. 24(5) |
| ISSN: | 0196-9781 |
| Popis: | Humanin peptides (including HN, HNG and other mutants) were reported previously that antagonize neurotoxicity caused by various familial Alzheimer's disease (FAD) genes and Abeta derivatives. Herein, we describe the aggregation dynamics and the representative morphological characteristics of Abeta(1-40) after different time of addition humanin peptides, which revealed that (a) the interactions of both HN and HNG with Abeta(1-40) induced quick and significant increase of light-scattering intensity, and (b) HNG also caused obvious morphological alteration from fibrillary to amorphous. In the meantime, the experiments also revealed that the interaction of HNG with Abeta(1-40) could decrease Abeta(1-40)-induced calcium rise, an initial event accompanying Abeta(1-40)-induced apoptosis of cultured neurons. Our results indicate that HNG can protect neurons by altering Abeta(1-40) morphology. |
| Databáze: | OpenAIRE |
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