Identifying diagnostic endocrine markers and changes in endometrial gene expressions during pyometra in cats
| Autor: | Marta J. Siemieniuch, Ewelina Jursza-Piotrowska |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Leukotrienes Leukotriene B4 Gene Expression Estrous Cycle 6-Ketoprostaglandin F1 alpha Medroxyprogesterone Acetate Biology Endometrium 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Pyometra Internal medicine medicine Medroxyprogesterone acetate Endocrine system Animals Estrous cycle 030219 obstetrics & reproductive medicine CATS Leukotriene C4 0402 animal and dairy science 04 agricultural and veterinary sciences medicine.disease 040201 dairy & animal science Toll-Like Receptor 2 Up-Regulation Toll-Like Receptor 4 medicine.anatomical_structure chemistry Cats lipids (amino acids peptides and proteins) Animal Science and Zoology Female Developmental Biology medicine.drug |
| Zdroj: | Reproductive biology. 16(2) |
| ISSN: | 2300-732X |
| Popis: | Pyometra is a significant reproductive problem in cats. The aims of this study were to evaluate (i) the immunological profile of queens by studying plasma concentrations of metabolites of prostacyclin I2 (6-keto-PGF1α), leukotriene B4 (LTB4) and leukotriene C4 (LTC4); and (ii) the gene transcription profiles of Toll-like receptors (TLRs) 2 and 4 (TLR2/4), PGE2-synthase (PGES), PGF2α-synthase (PGFS) and prostaglandin-endoperoxide synthase 2 (PTGS2) in the feline endometrium throughout the estrous cycle, after medroxyprogesterone acetate (MPA) treatment and during pyometra. The concentration of plasma 6-keto-PGF1α in pyometra was increased in comparison to other groups studied (p |
| Databáze: | OpenAIRE |
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