Clinical analysis of ultrasound-guided radiofrequency ablation for recurrent colorectal liver metastases after hepatectomy

Autor: Shu-yi Lv, Xiaoxiang Fan, Xiao-yu Dai, Yan Zhang, Meiwu Zhang, Jian-pei Zhao, Dafeng Mao
Rok vydání: 2020
Předmět:
Male
Percutaneous
Radiofrequency ablation
medicine.medical_treatment
law.invention
Liver metastases
0302 clinical medicine
law
Surgical oncology
Repeat hepatic resection
Aged
80 and over
Clinical pathology
Clinical outcome
Liver Neoplasms
Middle Aged
Prognosis
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Survival Rate
surgical procedures
operative
Liver
Oncology
Chemotherapy
Adjuvant
030220 oncology & carcinogenesis
Catheter Ablation
Female
030211 gastroenterology & hepatology
Radiology
Recurrence rate
Colorectal Neoplasms
therapeutics
Ultrasound-guided
Adult
Reoperation
medicine.medical_specialty
lcsh:Surgery
lcsh:RC254-282
Disease-Free Survival
03 medical and health sciences
medicine
Hepatectomy
Humans
Survival rate
Ultrasonography
Interventional
Survival analysis
Aged
Retrospective Studies
business.industry
Research
lcsh:RD1-811
Surgery
Liver function
Neoplasm Recurrence
Local
business
Follow-Up Studies
Zdroj: World Journal of Surgical Oncology, Vol 18, Iss 1, Pp 1-9 (2020)
World Journal of Surgical Oncology
ISSN: 1477-7819
Popis: Background RFA is designed to produce localized tumor destruction by heating the tumor and surrounding liver tissue, especially suitable for patients who do not qualify for hepatic resection. Many studies have reported that RFA was inferior to hepatectomy in the treatment of recurrent colorectal liver metastases. However, strong evidence is lacking in the literature. This study aimed to investigate the effect and clinical outcome of percutaneous ultrasound-guided RFA and repeat hepatic resection for recurrent colorectal liver metastases after hepatectomy. Methods From January 2007 to January 2014, 194 patients with recurrent colorectal liver metastases after hepatectomy diagnosed in our hospital was performed, and then divided into two groups based on different regimens: repeat hepatic resection group and RFA group. The clinical data of the two groups were analyzed. After treatment, the liver function-related indexes, complication rate, survival rate, and tumor recurrence of the two groups were recorded. The difference in short-term and long-term effects between repeat hepatic resection and RFA was identified by propensity score analysis. Results The number of metastases and the proportion of left and right lobe involved by tumor and preoperative chemotherapy in the RFA group were higher than those in the repeat hepatic resection group. The clinical data showed no significant difference between the two groups after using propensity score analysis. Compared with the RFA group, the liver function of the repeat hepatic resection group was significantly improved. After adjustment for potential confounders, no significant difference in liver function-related indexes was found between RFA and repeat hepatic resection, and the incidence of complications in the RFA group was lower. In survival analysis, there was no significant difference in OS and DFS between the two groups. Conclusions RFA is a safe and effective therapeutic option for patients with recurrent colorectal liver metastases after hepatectomy.
Databáze: OpenAIRE
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