Açaí (Euterpe oleracea Martius) supplementation improves oxidative stress biomarkers in liver tissue of dams fed a high-fat diet and increases antioxidant enzymes' gene expression in offspring
Autor: | Melina Oliveira de Souza, Marcelo Eustáquio Silva, Priscila Oliveira Barbosa, Maraísa Porfíria S. Silva, Gabrielly Thaís dos Santos, Renata Nascimento de Freitas, Giovanna Bermano |
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Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
GPX1 Antioxidant medicine.medical_treatment Gene Expression medicine.disease_cause Antioxidants chemistry.chemical_compound Mice 0302 clinical medicine Superoxide Dismutase-1 Glutathione Peroxidase GPX1 Non-alcoholic Fatty Liver Disease Pregnancy chemistry.chemical_classification biology Glutathione peroxidase Fatty liver General Medicine Organ Size Malondialdehyde Liver Catalase 030220 oncology & carcinogenesis Female Redox metabolism Maternal high-fat diet medicine.medical_specialty Offspring Euterpe Açaí RM1-950 Diet High-Fat 03 medical and health sciences Internal medicine medicine Animals Lactation Pharmacology Glutathione Peroxidase Body Weight medicine.disease Phospholipid Hydroperoxide Glutathione Peroxidase Rats Inbred F344 Rats Euterpe oleracea Martius Oxidative Stress 030104 developmental biology Endocrinology chemistry Dietary Supplements biology.protein Therapeutics. Pharmacology Oxidative stress Biomarkers |
Zdroj: | Biomedicine & Pharmacotherapy, Vol 139, Iss, Pp 111627-(2021) |
ISSN: | 1950-6007 |
Popis: | Lipids excess from an uterine environment can increase free radicals production of and thus induce oxidative status imbalance, a key factor for progression of non-alcoholic fatty liver disease (NAFLD) in offspring. Food antioxidant components in maternal diet may play an important role in preventing offspring metabolic disorders. The objective of the study was to evaluate the effects of acai pulp supplementation on maternal high-fat diet, by assessing activity and expression of antioxidant enzymes and biomarkers of oxidative stress in the liver. Female Fisher rats were divided into four groups and fed a control diet (C), a high-fat diet (HF), a control diet supplemented with acai (CA) and a high-fat diet supplemented with acai (HFA) before mating, during gestation and lactation. The effects of acai supplementation on oxidative stress biomarkers and antioxidant enzymes expression were evaluated in dams and male offspring after weaning. HFA diet increased body weight in dams, however reduced absolute and relative liver weight. There was a reduction in liver biomarkers of oxidative stress, malondialdehyde and carbonyl protein, as well as in catalase, glutathione peroxidase and superoxide dismutase activity. In offspring, HFA diet reduced liver weight and increased Gpx1, Gpx4 and Sod1 mRNA expression. These results suggest that acai is able to restore redox status, preventing oxidative damage in dams by a direct mechanism and to promote beneficial effects on expression of antioxidant defences related genes in offspring. |
Databáze: | OpenAIRE |
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