Açaí (Euterpe oleracea Martius) supplementation improves oxidative stress biomarkers in liver tissue of dams fed a high-fat diet and increases antioxidant enzymes' gene expression in offspring

Autor: Melina Oliveira de Souza, Marcelo Eustáquio Silva, Priscila Oliveira Barbosa, Maraísa Porfíria S. Silva, Gabrielly Thaís dos Santos, Renata Nascimento de Freitas, Giovanna Bermano
Rok vydání: 2020
Předmět:
0301 basic medicine
GPX1
Antioxidant
medicine.medical_treatment
Gene Expression
medicine.disease_cause
Antioxidants
chemistry.chemical_compound
Mice
0302 clinical medicine
Superoxide Dismutase-1
Glutathione Peroxidase GPX1
Non-alcoholic Fatty Liver Disease
Pregnancy
chemistry.chemical_classification
biology
Glutathione peroxidase
Fatty liver
General Medicine
Organ Size
Malondialdehyde
Liver
Catalase
030220 oncology & carcinogenesis
Female
Redox metabolism
Maternal high-fat diet
medicine.medical_specialty
Offspring
Euterpe
Açaí
RM1-950
Diet
High-Fat
03 medical and health sciences
Internal medicine
medicine
Animals
Lactation
Pharmacology
Glutathione Peroxidase
Body Weight
medicine.disease
Phospholipid Hydroperoxide Glutathione Peroxidase
Rats
Inbred F344
Rats
Euterpe oleracea Martius
Oxidative Stress
030104 developmental biology
Endocrinology
chemistry
Dietary Supplements
biology.protein
Therapeutics. Pharmacology
Oxidative stress
Biomarkers
Zdroj: Biomedicine & Pharmacotherapy, Vol 139, Iss, Pp 111627-(2021)
ISSN: 1950-6007
Popis: Lipids excess from an uterine environment can increase free radicals production of and thus induce oxidative status imbalance, a key factor for progression of non-alcoholic fatty liver disease (NAFLD) in offspring. Food antioxidant components in maternal diet may play an important role in preventing offspring metabolic disorders. The objective of the study was to evaluate the effects of acai pulp supplementation on maternal high-fat diet, by assessing activity and expression of antioxidant enzymes and biomarkers of oxidative stress in the liver. Female Fisher rats were divided into four groups and fed a control diet (C), a high-fat diet (HF), a control diet supplemented with acai (CA) and a high-fat diet supplemented with acai (HFA) before mating, during gestation and lactation. The effects of acai supplementation on oxidative stress biomarkers and antioxidant enzymes expression were evaluated in dams and male offspring after weaning. HFA diet increased body weight in dams, however reduced absolute and relative liver weight. There was a reduction in liver biomarkers of oxidative stress, malondialdehyde and carbonyl protein, as well as in catalase, glutathione peroxidase and superoxide dismutase activity. In offspring, HFA diet reduced liver weight and increased Gpx1, Gpx4 and Sod1 mRNA expression. These results suggest that acai is able to restore redox status, preventing oxidative damage in dams by a direct mechanism and to promote beneficial effects on expression of antioxidant defences related genes in offspring.
Databáze: OpenAIRE
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