Higher NAFLD fibrosis score is associated with impaired eGFR
| Autor: | Jeng-Fu Yang, Chia-Yen Dai, Shu-Ching Lin, Chao-Ling Wang, Hung-Yi Chuang, Wen-Yi Lin, Yi-Shan Tsai, Meng-Hsuan Hsieh, Yi-Yu Chen, Yu-Kuei Hsu, Ming-Lung Yu, Chao-Kuan Huang, Kuan-Ta Wu, Wan-Long Chuang, Chia-Yi Lin, Ning-Chia Chang |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Liver Cirrhosis Male medicine.medical_specialty Waist Taiwan Renal function Disease Risk Assessment Severity of Illness Index Non-alcoholic Fatty Liver Disease Risk Factors Internal medicine Fibrosis score Humans Medicine Renal Insufficiency Chronic Risk factor Retrospective Studies Preventive healthcare lcsh:R5-920 business.industry Fatty liver General Medicine Middle Aged medicine.disease ROC Curve Female business lcsh:Medicine (General) Biomarkers Glomerular Filtration Rate Kidney disease |
| Zdroj: | Journal of the Formosan Medical Association, Vol 119, Iss 1, Pp 496-503 (2020) |
| ISSN: | 0929-6646 |
| Popis: | Background/Purpose: Chronic kidney disease (CKD) has become a worldwide health problem, leading to high morbidity and mortality, and non-alcoholic fatty liver disease (NAFLD) is considered a risk factor for CKD. The aim of this study was to explore the relationship between NAFLD fibrosis score (NFS) and the estimated glomerular filtration rate (eGFR), and identify possible risk factors related to the NFS among Taiwanese subjects. Methods: Subjects were enrolled from the database of the Department of Preventive Medicine of Kaohsiung Municipal Hsiao-Kang Hospital. The eGFR was calculated according to the Taiwanese Modification of Diet in Renal Disease (TMDRD) equation, and the NFS was employed to evaluate the fibrotic level. Results: In total, 11,376 subjects were enrolled in this study, with a mean age of 52.0 ± 6.81 years, including 4529 (39.8%) males. A fasting sugar level ≥100 mg/dL (OR = 1.70, 95% CI = 1.52–1.87) and an abnormal waist circumference (OR = 1.81, 95% CI = 1.65–1.99) were significant factors associated with NFS (p |
| Databáze: | OpenAIRE |
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