Iodinated thyrolipids: their possible role in homonogenesis
| Autor: | R. C. Shownkeen, M. Y. Mandlik, D H Shah, U. R. Thakare, D. N. Pahuja |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
medicine.medical_specialty
Sheep Time Factors Chemistry Endocrinology Diabetes and Metabolism Carcinoma Cystadenoma Thyroid Gland General Medicine In Vitro Techniques Lipid Metabolism Graves Disease Rats Iodine Radioisotopes Thyroxine Endocrinology Internal medicine medicine Animals Humans Thyroid Neoplasms Goiter Nodular Iodine |
| Zdroj: | Acta endocrinologica. 74(3) |
| ISSN: | 0001-5598 |
| Popis: | A total of 42 human thyroid glands (nodular goitre 9, adenoma with cystic degeneration 6; toxic goitre 10; carcinoma 14; and normal thyroid gland 3) were examined in vitro for iodination of an unidentified polar non-phosphatide lipid fraction (fraction II). The radioiodine incorporation in fraction II was 49.3 %, 43.6 %, 32.8 %, 20.7 %, and 22.0 % respectively in normal, nodular goitre, adenoma with cystic degeneration, toxic goitre and thyroid carcinoma. In vitro studies with surviving sheep thyroid slices did not show any relation between the iodination of fraction II and thyroxine formation over a period of 120 min. However, a highly significant correlation (r-value= 0.96375) was observed between the iodination of fraction II and thyroxine formation in vivo in the rat thyroid gland over a period of 24 h. We have previously postulated that iodination of fraction II may be interrelated to thyroxine formation. In the light of this hypothesis and the above results we suggest that the iodination of fraction II and thyroxine formation in the thyroid gland may be interrelated, the degree of iodination of fraction II being modulated by the amount of thyroxine formed within the thyroid gland. |
| Databáze: | OpenAIRE |
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