Unilateral Cervical Nodal Metastasis Is an Independent Prognostic Factor for Esophageal Squamous Cell Carcinoma Patients Undergoing Chemoradiotherapy: A Retrospective Study
| Autor: | Liru He, Lei Zhao, Jingxian Shen, Qiao Qiao Li, Shiliang Liu, Peng Zhang, Mian Xi, Meng Zhong Liu |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Pathology Esophageal Neoplasms Cancer Treatment lcsh:Medicine Biochemistry Gastroenterology Metastasis Basic Cancer Research Medicine and Health Sciences lcsh:Science Lymph node Multidisciplinary Squamous Cell Carcinomas Chemoradiotherapy Middle Aged Esophageal cancer Head and Neck Tumors Chemotherapy regimen medicine.anatomical_structure Oncology Research Design Lymphatic Metastasis Carcinoma Squamous Cell Female Research Article Adult medicine.medical_specialty Clinical Research Design Radiation Therapy Research and Analysis Methods Carcinomas Head and Neck Squamous Cell Carcinoma Internal medicine medicine Carcinoma Humans Esophagus Aged Retrospective Studies business.industry lcsh:R Biology and Life Sciences Cancers and Neoplasms medicine.disease Survival Analysis T-stage lcsh:Q business Biomarkers |
| Zdroj: | PLoS ONE, Vol 9, Iss 6, p e101332 (2014) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Purpose To determine the prognostic significance of unilateral cervical lymph nodal metastasis (CLNM) in patients with inoperable thoracic esophageal squamous cell carcinoma (SCC) and to identify significant prognostic factors in these patients. Patients and methods This retrospective study involved 395 patients with inoperable esophageal SCC treated with concurrent chemoradiotherapy. The patients were classified into three groups according to their cervical lymph node status: group A, no evidence of CLNM; group B, unilateral CLNM; group C, other distant metastases. Overall survival (OS) and progression-free survival (PFS) were calculated. Significant prognostic factors were identified using univariate and multivariate analyses. Results The 3-year OS rates in groups A, B and C were 46.7%, 33.5% and 8.3%, respectively (p |
| Databáze: | OpenAIRE |
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