Chronic Histiocytic Intervillositis With Trophoblast Necrosis Is a Risk Factor Associated With Placental Infection From Coronavirus Disease 2019 (COVID-19) and Intrauterine Maternal-Fetal Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Transmission in Live-Born and Stillborn Infants
| Autor: | Sophie Prevot, Rebecca R. J. Collins, Kristen Thomas, Mattia Bugatti, Alexandre J. Vivanti, Luisa Patanè, W. Tony Parks, Rebecca L. Linn, David Strybol, Alexandra Benachi, Denise Morotti, Raffaella A. Morotti, Bianca Pulinx, Marcella Baldewijns, Fabio Facchetti, Veena Rajaram, David A. Schwartz, Lukas Marcelis, Daniele De Luca |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Male PNEUMONIA Placenta Diseases Infectious Disease Transmission Research & Experimental Medicine medicine.disease_cause 0302 clinical medicine Pregnancy Risk Factors Pathology Vertical 030212 general & internal medicine reproductive and urinary physiology VERTICAL TRANSMISSION Coronavirus Infectious General Medicine Stillbirth Trophoblasts Medical Laboratory Technology WUHAN medicine.anatomical_structure Medicine Research & Experimental embryonic structures Female Adult COVID-19 Chorionic Villi Chronic Disease Humans Infant Newborn Necrosis Pregnancy Complications Infectious Retrospective Studies Infectious Disease Transmission Vertical ZIKA VIRUS Life Sciences & Biomedicine UNKNOWN ETIOLOGY Transplacental transmission CHINA Pathology and Forensic Medicine 03 medical and health sciences Syncytiotrophoblast Placenta medicine Fetus Science & Technology business.industry Transplacental Infant medicine.disease Newborn Pregnancy Complications body regions 030104 developmental biology Chronic histiocytic intervillositis Immunology business |
| Popis: | Context.—The number of neonates with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is increasing, and in a few there are reports of intrauterine infection.Objective.—To characterize the placental pathology findings in a preselected cohort of neonates infected by transplacental transmission arising from maternal infection with SARS-CoV-2, and to identify pathology risk factors for placental and fetal infection.Design.—Case-based retrospective analysis by a multinational group of 19 perinatal specialists of the placental pathology findings from 2 cohorts of infants delivered to mothers testing positive for SARS-CoV-2: live-born neonates infected via transplacental transmission who tested positive for SARS-CoV-2 after delivery and had SARS-CoV-2 identified in cells of the placental fetal compartment by molecular pathology, and stillborn infants with syncytiotrophoblast positive for SARS-CoV-2.Results.—In placentas from all 6 live-born neonates acquiring SARS-CoV-2 via transplacental transmission, the syncytiotrophoblast was positive for coronavirus using immunohistochemistry, RNA in situ hybridization, or both. All 6 placentas had chronic histiocytic intervillositis and necrosis of the syncytiotrophoblast. The 5 stillborn/terminated infants had placental pathology findings that were similar, including SARS-CoV-2 infection of the syncytiotrophoblast, chronic histiocytic intervillositis, and syncytiotrophoblast necrosis.Conclusions.—Chronic histiocytic intervillositis together with syncytiotrophoblast necrosis accompanies SARS-CoV-2 infection of syncytiotrophoblast in live-born and stillborn infants. The coexistence of these 2 findings in all placentas from live-born infants acquiring their infection prior to delivery indicates that they constitute a pathology risk factor for transplacental fetal infection. Potential mechanisms of infection of the placenta and fetus with SARS-CoV-2, and potential future studies, are discussed. |
| Databáze: | OpenAIRE |
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