Pentoxifylline stimulates human sperm motility both in vitro and after oral therapy
| Autor: | CY Hong, Shen, PH Chiang, SS Chen, RC Yang |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Infertility
Adult Male medicine.medical_specialty endocrine system Motility Administration Oral Biology In Vitro Techniques Asthenozoospermia Pentoxifylline Male infertility Andrology In vivo Internal medicine medicine Humans Pharmacology (medical) Sperm motility Infertility Male Pharmacology Sperm Count urogenital system medicine.disease Sperm Endocrinology Sperm Motility medicine.drug Research Article |
| Zdroj: | British journal of clinical pharmacology. 31(6) |
| ISSN: | 0306-5251 |
| Popis: | Pentoxifylline is a haemorrheologic agent often used in the treatment of peripheral vascular disorders. In this study, we measured sperm motility with a trans-membrane migration method and investigated the effect of this drug in the treatment of male infertility. We found that pentoxifylline increased motility of ejaculated spermatozoa in vitro from both normal and asthenozoospermic samples. After giving pentoxifylline to patients with asthenozoospermia for 3 months, sperm motility significantly increased, but sperm concentration did not increase. From the above results, it can be concluded that pentoxifylline is a useful drug in the treatment of normogonadotropic asthenozoospermia. |
| Databáze: | OpenAIRE |
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