A Possible Mechanism of NK Cell-lineage Granular Lymphocyte Proliferative Disorder (NK-GLPD) in a Patient with Chronic Active Epstein-Barr Virus Infection (CAEBV) and Severe Hypersensitivity to Mosquito Bites (SHMB)
| Autor: | Hideyuki Kobayashi, Masaru Ishii, Shiro Ohshima, Toyoshi Tatekawa, Norihiko Yamaguchi, Hideo Asada, Yukihiko Saeki, Taeko Ishii, Toru Mima, Ichiro Kawase |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Interleukin 2
Epstein-Barr Virus Infections Fas Ligand Protein Adolescent Lymphocyte Population In Vitro Techniques Lymphocyte Activation medicine.disease_cause Virus Herpesviridae Natural killer cell Hypersensitivity Internal Medicine Animals Humans Medicine IL-2 receptor education education.field_of_study Membrane Glycoproteins business.industry Insect Bites and Stings General Medicine Epstein–Barr virus Virology Lymphoproliferative Disorders Killer Cells Natural Culicidae medicine.anatomical_structure Chronic Disease Immunology Female business medicine.drug |
| Zdroj: | Internal Medicine. 41:651-656 |
| ISSN: | 1349-7235 0918-2918 |
| Popis: | We report the case of a young female patient with chronic active Epstein-Barr virus infection (CAEBV) and severe hypersensitivity to mosquito bites (SHMB). She showed a marked increase of NK cell population in peripheral blood. The NK cell population was suggested to be infected with EBV, and to be oligoclonal by Southern blotting using an EBV genome terminal-repeat probe. The NK cells aberrantly expressed CD25, a high affinity receptor for IL-2, and showed an augmented in vitro proliferative response to IL-2. Moreover, they also showed enhanced expression of both Fas-ligand and Bcl-2, and resistance to in vitro Fas-induced apoptotic cell death (Fas-ACD). Taken together, these observations suggested that both the augmentation of proliferative response to IL-2 and the decrease in Fas-ACD may cause NK cell lineage granular lymphocyte proliferative disorder (NK-GLPD) in patients with CAEBV and SHMB. |
| Databáze: | OpenAIRE |
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