Serum Fetuin-A levels in obese children with biopsy proven nonalcoholic fatty liver disease

Autor: Anna Alisi, Valerio Nobili, Antonella Puglianiello, Arianna Alterio, Daniela Germani, Stefano Cianfarani, Elena Inzaghi, Valentina Pampanini
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Male
Pediatric Obesity
alpha-2-HS-Glycoprotein
Endocrinology
Diabetes and Metabolism
medicine.medical_treatment
Biopsy
Medicine (miscellaneous)
Blood Pressure
Gastroenterology
Severity of Illness Index
Liver disease
0302 clinical medicine
Non-alcoholic Fatty Liver Disease
Risk Factors
Nonalcoholic fatty liver disease
Child
Children
Ultrasonography
Nutrition and Dietetics
medicine.diagnostic_test
Fatty liver
Fetuin-A
NAFLD
Obesity
Age Factors
Biomarkers
Body Composition
Female
Humans
Liver
Predictive Value of Tests
Waist Circumference
Settore MED/38
Liver biopsy
Cardiology and Cardiovascular Medicine
medicine.medical_specialty
030209 endocrinology & metabolism
03 medical and health sciences
Internal medicine
medicine
business.industry
Insulin
nutritional and metabolic diseases
medicine.disease
digestive system diseases
030104 developmental biology
Endocrinology
Blood pressure
business
Popis: Background and aims Fetuin-A has been proposed as a marker of liver damage in adults with obesity-related NAFLD. The aim of this study was to test serum fetuin-A concentrations in obese children with NAFLD diagnosed either by ultrasonography or by liver biopsy and to determine its applicability as predictive tool in pediatric NAFLD. Methods and results Metabolic parameters and fetuin-A levels were investigated in 81 obese children with NAFLD diagnosed by biopsy, 79 obese children with NAFLD defined by liver ultrasonography and 23 lean subjects. Serum fetuin-A correlated significantly with age, waist circumference, systolic blood pressure, fasting insulin and 2-h postload insulin during OGTT, HOMA-IR, ISI, CRP, and apo B levels. Obese children with NAFLD detected by ultrasonography had significantly higher fetuin-A levels compared to those with normal liver. In obese children who underwent liver biopsy, no significant differences were detected in fetuin-A levels between subject with nonalcoholic steatohepatitis and those with simple steatosis. Fetuin-A was not different between obese and lean children. Conclusion Fetuin-A is not related with the degree of liver damage in obese children with NAFLD and its routine measurement as marker of liver disease severity is therefore not recommended.
Databáze: OpenAIRE
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