Serum Fetuin-A levels in obese children with biopsy proven nonalcoholic fatty liver disease
Autor: | Anna Alisi, Valerio Nobili, Antonella Puglianiello, Arianna Alterio, Daniela Germani, Stefano Cianfarani, Elena Inzaghi, Valentina Pampanini |
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Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Male Pediatric Obesity alpha-2-HS-Glycoprotein Endocrinology Diabetes and Metabolism medicine.medical_treatment Biopsy Medicine (miscellaneous) Blood Pressure Gastroenterology Severity of Illness Index Liver disease 0302 clinical medicine Non-alcoholic Fatty Liver Disease Risk Factors Nonalcoholic fatty liver disease Child Children Ultrasonography Nutrition and Dietetics medicine.diagnostic_test Fatty liver Fetuin-A NAFLD Obesity Age Factors Biomarkers Body Composition Female Humans Liver Predictive Value of Tests Waist Circumference Settore MED/38 Liver biopsy Cardiology and Cardiovascular Medicine medicine.medical_specialty 030209 endocrinology & metabolism 03 medical and health sciences Internal medicine medicine business.industry Insulin nutritional and metabolic diseases medicine.disease digestive system diseases 030104 developmental biology Endocrinology Blood pressure business |
Popis: | Background and aims Fetuin-A has been proposed as a marker of liver damage in adults with obesity-related NAFLD. The aim of this study was to test serum fetuin-A concentrations in obese children with NAFLD diagnosed either by ultrasonography or by liver biopsy and to determine its applicability as predictive tool in pediatric NAFLD. Methods and results Metabolic parameters and fetuin-A levels were investigated in 81 obese children with NAFLD diagnosed by biopsy, 79 obese children with NAFLD defined by liver ultrasonography and 23 lean subjects. Serum fetuin-A correlated significantly with age, waist circumference, systolic blood pressure, fasting insulin and 2-h postload insulin during OGTT, HOMA-IR, ISI, CRP, and apo B levels. Obese children with NAFLD detected by ultrasonography had significantly higher fetuin-A levels compared to those with normal liver. In obese children who underwent liver biopsy, no significant differences were detected in fetuin-A levels between subject with nonalcoholic steatohepatitis and those with simple steatosis. Fetuin-A was not different between obese and lean children. Conclusion Fetuin-A is not related with the degree of liver damage in obese children with NAFLD and its routine measurement as marker of liver disease severity is therefore not recommended. |
Databáze: | OpenAIRE |
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