Evaluation of multidisciplinary team decisions in neuroendocrine neoplasms
| Autor: | Wouter T. Zandee, Elettra Merola, Karolina Poczkaj, Louis de Mestier, Heinz‐Josef Klümpen, Karen Geboes, Wouter W. de Herder, Alia Munir |
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| Přispěvatelé: | Internal Medicine, Oncology, CCA - Cancer Treatment and Quality of Life, Internal medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | European Journal of Cancer Care, 31(6):e13639. Wiley-Blackwell Publishing Ltd European journal of cancer care, 31(6):e13639. Wiley European journal of cancer care, 31(6):e13639. Wiley-Blackwell European Journal of Cancer Care, 31(6):e13639. Wiley-Blackwell Zandee, W T, Merola, E, Poczkaj, K, de Mestier, L, Klümpen, H-J, Geboes, K, de Herder, W W & Munir, A 2022, ' Evaluation of multidisciplinary team decisions in neuroendocrine neoplasms : Impact of expert centres ', European Journal of Cancer Care, vol. 31, no. 6, e13639 . https://doi.org/10.1111/ecc.13639 |
| ISSN: | 0961-5423 |
| DOI: | 10.1111/ecc.13639 |
| Popis: | OBJECTIVE: To evaluate the impact of multidisciplinary team (MDT) meetings on the management of patients with neuroendocrine neoplasms (NENs).METHODS: All newly referred gastro-entero-pancreatic (GEP)-NEN patients discussed from 1 April to 1 October 2017 in the MDT of seven European expert centres were prospectively included. The impact on patients' management was defined as a change in diagnosis, grade, stage or treatment.RESULTS: A total of 292 patients were included, mainly small intestinal (siNENs) (32%) and pancreatic NENs (28%), with distant metastases in 51%. Patients had received prior surgery in 43% of cases and prior medical treatment in 32%. A significant change occurred in 61% of NENs: 7% changes in diagnosis, 8% in grade and 16% in stage. The MDT recommended a new treatment for 51% of patients, mainly surgery (9%) or somatostatin analogues (20%). A significant change was most frequently observed in patients with Stage IV disease (hazard ratio [HR] 3.6, 95% confidence interval [CI]: 1.9-6.9 vs. Stage I) and G2 NENs (vs. G1, HR 2.1 95% CI: 1.2-3.8).CONCLUSION: NEN-dedicated MDT discussion in expert centres yields significant management changes in over 60% of patients and thus represents the gold standard for the management of these patients. |
| Databáze: | OpenAIRE |
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