A whole genome association study in Finnish multiple sclerosis patients with 3669 markers
| Autor: | Juhani Ruutiainen, M Laaksonen, Alastair Compston, Theodora Thorlacius, Stephen Sawcer, Ragnheidur Fossdal, Aslaug Jonasdottir, Jorma Ilonen, Jeff Gulcher, Kjartan Benediktsson |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Multiple Sclerosis Genotype Immunology Genome-wide association study Major histocompatibility complex Genome Polymerase Chain Reaction Gene Frequency medicine Demyelinating disease Immunology and Allergy Humans Alleles Finland Genetics Linkage (software) biology Genome Human Multiple sclerosis medicine.disease Physical Chromosome Mapping Neurology Case-Control Studies biology.protein Microsatellite Female Neurology (clinical) Pooled dna Microsatellite Repeats |
| Zdroj: | Journal of neuroimmunology. 143(1-2) |
| ISSN: | 0165-5728 |
| Popis: | Multiple sclerosis (MS) is a demyelinating disease of the central nervous system with complex genetic background. In the present study, based in the Finnish population, we typed a large number of microsatellite markers in separately pooled DNA samples from 195 MS patients and 205 controls. A total of 108 markers showed evidence of association. Five genomic regions containing two or more of these markers within a 1-Mb interval were identified, 1q43, 2p16, 4p15, 4q34 and 6p21 (the MHC region). Substantial overlap with previously published linkage genome screens is also seen. |
| Databáze: | OpenAIRE |
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