Mucosal neuromas and plexiform neurofibromas: an immunocytochemical study
| Autor: | G. Budzilovich, J. Jagirdar, H. Adelman, J. Cangiarella, And M A Greco |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Immunocytochemistry Histogenesis Pathology and Forensic Medicine Immunophenotyping Pheochromocytoma Diagnosis Differential Neuroma Plexiform neurofibroma Antigens Neoplasm medicine Humans Neurofibromatosis Multiple endocrine neoplasia Child Membrane Glycoproteins Mucous Membrane Neurofibroma business.industry Eye Neoplasms Mucin-1 Multiple Endocrine Neoplasia Mouth Mucosa Histology Anatomy medicine.disease Immunohistochemistry medicine.anatomical_structure Pediatrics Perinatology and Child Health Female Mouth Neoplasms Perineurium business Biomarkers |
| Zdroj: | Pediatric pathology. 13(3) |
| ISSN: | 0277-0938 |
| Popis: | Mucosal neuromas (MN), a component of multiple endocrine neoplasia (MEN) type IIb, may be confused histologically with plexiform neurofibromas (PN), a component of neurofibromatosis. The ability to distinguish between these two markers for different genetic diseases is crucial, as the risk of development of medullary thyroid carcinoma and pheochromocytoma in affected patients with MEN IIb is great. We studied two cases each of MN and PN by immunocytochemistry (IC). Epithelial membrane antigen (EMA) proved to be the most useful marker. MN consisted of bundles of disorganized and tortuous nerve fibers surrounded by a thickened perineurium that expressed the cellular phenotype EMA(+), S-100(‐). PN consisted of enlarged neroe fascicles with a loose myxoid stroma and was EMA negative. Thus, IC highlighted the differing pattern of growth and histogenesis of the proliferating cells in the two lesions and is likely to be especially useful in those lesions with atypical histology. |
| Databáze: | OpenAIRE |
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