Gene-Environment Interactions of Circadian-Related Genes for Cardiometabolic Traits
| Autor: | Dashti, Hassan S., Follis, Jack L., Smith, Caren E., Tanaka, Toshiko, Garaulet, Marta, Gottlieb, Daniel J., Hruby, Adela, Jacques, Paul F., Kiefte-de Jong, Jessica C., Lamon-Fava, Stefania, Scheer, Frank A.J.L., Bartz, Traci M., Kovanen, Leena, Wojczynski, Mary K., Frazier-Wood, Alexis C., Ahluwalia, Tarunveer S., Perälä, Mia-Maria, Jonsson, Anna, Muka, Taulant, Kalafati, Ioanna P., Mikkilä, Vera, Ordovás, José M., Lemaitre, Rozenn N., Partonen, Timo, Ebeling, Tapani, Hopkins, Paul N., Paternoster, Lavinia, Lahti, Jari, Hernandez, Dena G., Toft, Ulla, Saxena, Richa, Vitezova, Anna, Kanoni, Stavroula, Raitakari, Olli T., Psaty, Bruce M., Perola, Markus, Männistö, Satu, Straka, Robert J., Hansen, Torben, Räikkönen, Katri, Ferrucci, Luigi, Grarup, Niels, Johnson, W. Craig, Rallidis, Loukianos, Kähönen, Mika, Siscovick, David S., Havulinna, Aki S., Astrup, Arne, Jørgensen, Torben, Chen, Tzu-An, Hofman, Albert, Deloukas, Panos, Viikari, Jorma S.A., Mozaffarian, Dariush, Pedersen, Oluf, Rotter, Jerome I., Uitterlinden, André G., Seppälä, Ilkka, Tiemeier, Henning, Salomaa, Veikko, Gharib, Sina A., Borecki, Ingrid B., Arnett, Donna K., Sørensen, Thorklid I.A., Eriksson, Johan G., Bandinelli, Stefania, Linneberg, Allan, Rich, Stephen S., Franco, Oscar H., Dedoussis, George, Lehtimäki, Terho |
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| Přispěvatelé: | Epidemiology |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Population 030209 endocrinology & metabolism Type 2 diabetes 03 medical and health sciences 0302 clinical medicine Insulin resistance SDG 3 - Good Health and Well-being Internal medicine Internal Medicine medicine Circadian rhythm Allele Epidemiology/Health Services Research education 030304 developmental biology Glycemic Advanced and Specialized Nursing 0303 health sciences education.field_of_study business.industry medicine.disease Obesity Endocrinology Metabolic syndrome business |
| Zdroj: | Diabetes Care, 38(8), 1456-1466. American Diabetes Association Inc. Diabetes Care |
| ISSN: | 0149-5992 |
| DOI: | 10.2337/dc14-2709 |
| Popis: | OBJECTIVE Common circadian-related gene variants associate with increased risk for metabolic alterations including type 2 diabetes. However, little is known about whether diet and sleep could modify associations between circadian-related variants (CLOCK-rs1801260, CRY2-rs11605924, MTNR1B-rs1387153, MTNR1B-rs10830963, NR1D1-rs2314339) and cardiometabolic traits (fasting glucose [FG], HOMA-insulin resistance, BMI, waist circumference, and HDL-cholesterol) to facilitate personalized recommendations. RESEARCH DESIGN AND METHODS We conducted inverse-variance weighted, fixed-effect meta-analyses of results of adjusted associations and interactions between dietary intake/sleep duration and selected variants on cardiometabolic traits from 15 cohort studies including up to 28,190 participants of European descent from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. RESULTS We observed significant associations between relative macronutrient intakes and glycemic traits and short sleep duration ( CONCLUSIONS Our results suggest that lower carbohydrate intake and normal sleep duration may ameliorate cardiometabolic abnormalities conferred by common circadian-related genetic variants. Until further mechanistic examination of the nominally significant interactions is conducted, recommendations applicable to the general population regarding diet—specifically higher carbohydrate and lower fat composition—and normal sleep duration should continue to be emphasized among individuals with the investigated circadian-related gene variants. |
| Databáze: | OpenAIRE |
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