Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo
Autor: | Christiane Pfeiffer, J Stein, H Ketelaar, S Southwood, Kim Bottomly, A Sette |
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Rok vydání: | 1995 |
Předmět: |
Molecular Sequence Data
Immunology Antigen presentation Receptors Antigen T-Cell Priming (immunology) Mice Inbred Strains Streptamer Biology Ligands Lymphocyte Activation Interferon-gamma Mice Th2 Cells T-Lymphocyte Subsets Animals Humans Immunology and Allergy Cytotoxic T cell IL-2 receptor Antigen-presenting cell Antigen Presentation Base Sequence Histocompatibility Antigens Class II CD28 Cell Differentiation Articles Th1 Cells Natural killer T cell Molecular biology Peptide Fragments Mutagenesis Site-Directed Collagen Interleukin-4 Signal Transduction |
Zdroj: | The Journal of Experimental Medicine |
ISSN: | 1540-9538 0022-1007 |
Popis: | Antigen priming of naive CD4 T cells can generate effector CD4 T cells that produce interleukin 4 (T helper [Th]2-like) or interferon-gamma (Th1-like). Using a system in which priming leads to responses dominated by one or the other of these cell types, we show that varying either the antigenic peptide or the major histocompatibility complex class II molecule can determine whether Th1-like or Th2-like responses are obtained. Our results show that peptide/major histocompatibility complex class II complexes that interact strongly with the T cell receptor favor generation of Th1-like cells, while those that bind weakly favor priming of Th2-like T cells. Thus, signals from the T cell receptor can influence the differentiation of CD4 T cells into specific types of effector cells. |
Databáze: | OpenAIRE |
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