Ischemia-reperfusion Injury in the Transplanted Lung: A Literature Review
| Autor: | Walker Julliard, Chetan Pasrija, David J. Kaczorowski, Nikhil K. Prasad, Tara Talaie, Laura DiChiacchio, Christine L Lau, Yunge Zhao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Transplantation
medicine.medical_specialty Lung business.industry medicine.medical_treatment Ischemia Transplanted lung lcsh:Surgery Primary Graft Dysfunction Review lcsh:RD1-811 030230 surgery respiratory system medicine.disease 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure surgical procedures operative medicine Lung transplantation 030211 gastroenterology & hepatology Intensive care medicine business Reperfusion injury |
| Zdroj: | Transplantation Direct, Vol 7, Iss 2, p e652 (2021) Transplantation Direct |
| ISSN: | 2373-8731 |
| DOI: | 10.1097/TXD.0000000000001104 |
| Popis: | Lung ischemia-reperfusion injury (LIRI) and primary graft dysfunction are leading causes of morbidity and mortality among lung transplant recipients. Although extensive research endeavors have been undertaken, few preventative and therapeutic treatments have emerged for clinical use. Novel strategies are still needed to improve outcomes after lung transplantation. In this review, we discuss the underlying mechanisms of transplanted LIRI, potential modifiable targets, current practices, and areas of ongoing investigation to reduce LIRI and primary graft dysfunction in lung transplant recipients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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