Opportunistic infections and organ-specific diseases in HIV-1-infected children: a cohort study (1990-2006)
Autor: | S, Guillén, L, García San Miguel, S, Resino, J M, Bellón, I, González, S, Jiménez de Ory, M A, Muñoz-Fernández, M L, Navarro, M D, Gurbindo, M I, de José, M J, Mellado, P, Martín-Fontelos, M I, Gonzalez-Tomé, J, Martinez, J, Beceiro, M A, Roa, J T, Ramos, C, Calvo |
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Rok vydání: | 2010 |
Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Time Factors Anti-HIV Agents Population HIV Infections Cohort Studies Acquired immunodeficiency syndrome (AIDS) Antiretroviral Therapy Highly Active medicine Humans Pharmacology (medical) Child education Survival rate education.field_of_study AIDS-Related Opportunistic Infections business.industry Health Policy Incidence (epidemiology) Infant Newborn Bacterial pneumonia Infant virus diseases Viral Load medicine.disease CD4 Lymphocyte Count Survival Rate Treatment Outcome Infectious Diseases Spain Child Preschool Immunology Cohort HIV-1 Female business Viral load Cohort study |
Zdroj: | HIV Medicine. 11:245-252 |
ISSN: | 1468-1293 1464-2662 |
DOI: | 10.1111/j.1468-1293.2009.00768.x |
Popis: | Objectives Highly active antiretroviral therapy (HAART) has dramatically changed the natural history of HIV infection in children, but there are few studies in the literature about the incidence of clinical manifestations after HAART in this population, compared with adults. The aim of this study was to describe the influence of the widespread use of HAART on the development of opportunistic infections and organ-specific diseases in HIV-infected children. Methods An observational study of a cohort of 366 vertically HIV-infected children followed from 1990 to 2006 was carried out. According to the main antiretroviral protocol used, three calendar periods (CPs) were defined and compared: CP1 (1990–1996: no patients on HAART), CP2 (1997–1999: 60% on HAART). Results Children experienced a progressive increase in CD4 T cell count (P |
Databáze: | OpenAIRE |
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