Is there an increased maternal-infant prevalence of Factor V Leiden in association with severe pre-eclampsia?
| Autor: | Michelle McNiven, Lea Currie, Michael J. Peek, Ian Prosser, Julia Mansour, Jennifer Ridgway |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male medicine.medical_specialty Heterozygote Preeclampsia Cohort Studies Pre-Eclampsia Pregnancy Risk Factors medicine Factor V Leiden Humans Genetic Predisposition to Disease Prospective Studies Prospective cohort study Fetus Eclampsia Obstetrics business.industry Outcome measures Infant Newborn Obstetrics and Gynecology Factor V medicine.disease female genital diseases and pregnancy complications Immunology Mutation Female business Cohort study |
| Zdroj: | BJOG : an international journal of obstetrics and gynaecology. 109(2) |
| ISSN: | 1470-0328 |
| Popis: | Objective To compare the prevalence of the Factor V Leiden mutation in children and maternal–infant pairs in pregnancies affected by severe pre-eclampsia with unmatched normal controls. Design Prospective cohort study. Setting Department of Women's and Children's Health, The Canberra Hospital, Garran, ACT, Australia. Sample Forty-eight maternal–infant pairs where the index pregnancy was affected by severe pre-eclampsia; 46 unmatched maternal–infant pairs where the index pregnancy was defined as normal. Methods DNA analysis of cheek swab samples obtained from maternal–infant pairs for the Factor V Leiden mutation. Main outcome measure The prevalence of the Factor V Leiden mutation in mothers, infants and maternal–infant pairs in association with severe pre-eclampsia compared with unmatched controls. Results No difference was detected in the prevalence of Factor V Leiden mutation between the women and children of both groups, nor the maternal–infant pairs from each group. Conclusions No evidence was found of an increased prevalence of the Factor V Leiden mutation in either the mothers or children in association with severe pre-eclampsia. This result argues against a Factor V Leiden fetal or maternal contribution to the development of severe pre-eclampsia. |
| Databáze: | OpenAIRE |
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