Predicting response to amitriptyline in posttraumatic stress disorder
| Autor: | L. Erickson, Jesse O. Cavenar, Elliott B. Hammett, William B. Saunders, Rebecca D. Smith, Jonathan R. T. Davidson, Harold Kudler, Steven Lipper, Steven L. Mahorney, Roy Stein |
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| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty Amitriptyline Comorbidity Severity of Illness Index Life Change Events Placebos Stress Disorders Post-Traumatic Double-Blind Method Rating scale mental disorders medicine Humans Psychiatry Probability Psychiatric Status Rating Scales Depressive Disorder Traumatic stress Hamilton Rating Scale for Depression Middle Aged medicine.disease Neuroticism Anxiety Disorders Psychiatry and Mental health Treatment Outcome Clinical Global Impression Anxiety medicine.symptom Psychology Anxiety disorder Clinical psychology |
| Zdroj: | The American journal of psychiatry. 150(7) |
| ISSN: | 0002-953X |
| Popis: | Objective: This study evaluated the relation between baseline clinical phenomena and response to amitriptyline in patients with posttraumatic stress disorder (PTSD). Method: Data were obtained from an 8-week placebo-controlled, double-blind study of combat veterans. Bivariate and multivariate statistics were used to evaluate the relations between the following variables and outcome: age, depression, anxiety, severity of PTSD symptoms, personality, psychiatric comorbidity, level ofexposure to trauma, and individual symptoms of depression, anxiety, and traumatic stress. Outcome measures were scores on the Clinical Global Impression scale, Hamilton Rating Scale for Depression, Hamilton Rating Scale for Anxiety, and Impact of Event Scale. Results: Drug response was related to lower baseline levels of depression, neuroticism, combat intensity, anxious mood, impaired concentration, somatic symptoms, feelings ofguilt, and one intrusion and four avoidance symptoms ofPTSD. Conclusions: The results demonstrate that response to amitriptyline is related to measures of depression, anxiety, PTSD, personality, and intensity of combat trauma. Similar relationships were not observed in the placebo group, suggesting a specific relationship to the drug. (AmJ Psychiatry1993; 150:1024-1029) |
| Databáze: | OpenAIRE |
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