Non-association of IL-16 rs4778889 T/C polymorphism with cancer risk in Asians: a meta-analysis
| Autor: | Li-Qin Zhao, Lin-Lin Xu, Zhi-Chun Song, Zhan-Sheng Zhu, Kun Shang |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Cancer Research
medicine.medical_specialty Epidemiology Bioinformatics Gastroenterology Polymorphism (computer science) Risk Factors Internal medicine Neoplasms Medicine Humans Genetic Predisposition to Disease Interleukin-16 Polymorphism Genetic business.industry Cancer type Public Health Environmental and Occupational Health Cancer Odds ratio medicine.disease Prognosis Confidence interval Oncology Sample size determination Meta-analysis Case-Control Studies Cancer risk business |
| Zdroj: | Asian Pacific journal of cancer prevention : APJCP. 15(2) |
| ISSN: | 2476-762X |
| Popis: | The IL-16 rs4778889 T/C polymorphism is associated with cancer risk. However, the results are conflicting. We performed this meta-analysis to derive a more precise estimation of the relationship. A comprehensive literature search was performed using PubMed, Embase and Web of Science databases. Odds ratio (OR) and 95% confidence interval (CI) were used to assess the strength of association. A total of 6 studies including 1,603 cases and 2,342 controls were identified. With all studies involved, results showed no statistically significant association between IL-16 rs4778889 T/C polymorphism and cancer risk (CC vs. CT+TT: OR=0.74, 95%CI: 0.55-1.02, Ph=0.15; CC+CT vs. TT: OR=0.89, 95%CI: 0.72-1.10, Ph =0.03; CC vs. TT: OR=0.73, 95%CI: 0.53- 1.00, Ph =0.08; CT vs. TT: OR=0.91, 95%CI: 0.79-1.05, Ph =0.08; C vs. T: OR=0.89, 95%CI: 0.74-1.07, Ph =0.02). In addition, the results were not changed when studies were stratified by cancer type. However, to verify our findings, it is essential to perform more well-designed studies with larger sample sizes in the future. |
| Databáze: | OpenAIRE |
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