SOLUBLE LEPTIN RECEPTOR LEVELS IN PATIENTS WITH ANOREXIA NERVOSA
| Autor: | Kotrlíková E, Hana Papezova, Jarmila Krizova, Martin Haluzik, Denisa Haluzikova, Jan Jiskra, Tomas Haas, Jitka Parizkova |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Leptin
medicine.medical_specialty Anorexia Nervosa medicine.medical_treatment Receptors Cell Surface Anorexia nervosa Body Mass Index Endocrinology Reference Values Internal medicine medicine Humans Insulin In patient Leptin receptor business.industry digestive oral and skin physiology General Medicine Anthropometry medicine.disease Adipose Tissue Solubility Food Serum leptin Body Composition Receptors Leptin Female business Body mass index |
| Zdroj: | Endocrine Research. 28:199-205 |
| ISSN: | 1532-4206 0743-5800 |
| DOI: | 10.1081/erc-120015058 |
| Popis: | To examine whether changes of serum soluble leptin receptor levels (S-LEPR) can modify leptin half-life and its tissue effects. The aim of our study was to measure S-LEPR levels in patients with anorexia nervosa (AN) before and 6 weeks after partial refeeding.Anthropometric variables, serum leptin, S-LEPR, insulin, cortisol and TNF-alpha were measured in 15 AN patients before and after partial refeeding and 15 healthy control women.S-LEPR levels in AN patients were significantly higher than in healthy subjects (26.8 +/- 8.1 vs. 16.36+/-2.6U/mL, p0.01) and were not affected by partial refeeding (26.8 +/- 8.1 vs. 24.2 +/- 6.1 U/mL). In contrast, body mass index (BMI), body fat content, and serum leptin levels in AN patients increased significantly after partial refeeding. Except for the inverse relationship of S-LEPR levels to BMI and body fat content no clear relationship of this parameter to serum leptin, cortisol, insulin or TNF-alpha was found.S-LEPR levels are significantly increased in AN patients and this increase is unaffected by partial refeeding. The possibility of etiological role of increased S-LEPR levels in AN patients by affecting leptin central and/or peripherial effects should be further elucidated. |
| Databáze: | OpenAIRE |
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