The role of environment in the pathogenesis of keratoconus
| Autor: | Otávio de Azevedo Magalhães, Mauro Cabral Gonçalves, Damien Gatinel |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Diagnostic Imaging
Keratoconus genetic structures business.industry Environmental Exposure General Medicine medicine.disease Bioinformatics eye diseases Cornea Pathogenesis 03 medical and health sciences Ophthalmology 0302 clinical medicine 030221 ophthalmology & optometry medicine Humans Corneal deformation Patient awareness business Ocular surface 030217 neurology & neurosurgery |
| Zdroj: | Current Opinion in Ophthalmology. 32:379-384 |
| ISSN: | 1531-7021 1040-8738 |
| Popis: | Purpose of review This study was conducted to demonstrate the importance of the environment in keratoconus (KC) genesis. Recent findings Genetic-related connective tissue disorders demonstrate the inconsistency of theories regarding KC pathogenesis since no corneal steepening was observed in the majority of these patients. Despite recent advances and decades of research into the genetics of KC, the identification of disease-causing KC genes has been frustrating. Variants found based on genome-wide and next-generation sequencing only seem to account for a small number of cases or play a limited role in KC pathogenesis. Summary The literature shows that mechanical manipulation may be the common underlying factor or the indispensable act precipitating the cascade of events leading to permanent corneal deformation. Hence, ophthalmologists have the opportunity to increase patient awareness about eye manipulation repercussions and treatment for ocular surface disorders. Video abstract http://links.lww.com/COOP/A42. |
| Databáze: | OpenAIRE |
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