Radionuclide assessment of myocardial injury in a heterotopic rat heart transplant model
| Autor: | W. J. Hannan, D. J. Wheatley, A.L. Muir, C. G. A. Mcgregor, A.F. Smith |
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| Rok vydání: | 1984 |
| Předmět: |
Graft Rejection
Male medicine.medical_specialty Pathology Technetium Tc 99m Pyrophosphate Time Factors Transplanted heart Pyrophosphate chemistry.chemical_compound Coronary Circulation Internal medicine medicine Animals Radiology Nuclear Medicine and imaging Radionuclide Imaging biology business.industry Technetium Heart Rats Inbred Strains Rat heart Rats Diphosphates Transplantation Donor heart chemistry Sodium iodide biology.protein Cardiology Heart Transplantation Creatine kinase business |
| Zdroj: | International Journal of Nuclear Medicine and Biology. 11:189-194 |
| ISSN: | 0047-0740 |
| Popis: | The use of heterotopic cardiac transplantation in rats of isogeneic strain has been investigated as a model of diffuse myocardial ischaemic injury. This model allowed the production of controlled graded injury prior to implantation of the donor heart in a recipient animal. In 21 animals the uptake of technetium-99 m labelled pyrophosphate ([ 99m Tc]PYP) in the transplanted heart, as measured by a γ-camera/computer system, agreed well with that determined by direct organ counting in a sodium iodide well-type detector ( P 99m Tc]PYP in the transplanted heart, as determined using the γ-camera, was found to be at 2 days after transplantation and 1 to 2 h after injection. For three groups each consisting of 25 rats the donor hearts were stored for 0, 30 or 90 min to produce a range of myocardial damage. For these groups there was no significant increase in creatine kinase with increasing storage time. For each group the uptake of [ 99m Tc]PYP was significantly higher ( P |
| Databáze: | OpenAIRE |
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