Understanding Circadian Mechanisms of Sudden Cardiac Death: A Report From the National Heart, Lung, and Blood Institute Workshop, Part 2: Population and Clinical Considerations

Autor: Kalyanam Shivkumar, Frank A.J.L. Scheer, Alfred L. George, Martica H. Hall, Virend K. Somers, Martin E. Young, Christine Garnett, Prince J. Kannankeril, Steven Shea, Crystal M. Ripplinger, Joshua I. Goldhaber, Jeanne M. Nerbonne, Michael H. Smolensky, Joseph Bass, Tracey O. Hermanstyne, Jeanne F. Duffy, Mukesh K. Jain, Ron C. Anafi, Ravi C. Balijepalli, Brian P. Delisle
Rok vydání: 2021
Předmět:
Medical Physiology
Circadian clock
population
Disease
Cardiorespiratory Medicine and Haematology
Cardiovascular
Sudden cardiac death
and Blood Institute (U.S.)
circadian clock
2.1 Biological and endogenous factors
genetics
Aetiology
Lung
education.field_of_study
and Blood Institute
Circadian Rhythm
Death
Heart Disease
medicine.anatomical_structure
Population Surveillance
Respiratory
Cardiology
Sleep Research
Cardiology and Cardiovascular Medicine
Cardiac
circadian rhythm
medicine.medical_specialty
Clinical Sciences
Population
Unexpected death
Article
sudden cardiac death
Physiology (medical)
Internal medicine
medicine
Humans
Circadian rhythm
education
Heart Disease - Coronary Heart Disease
business.industry
Prevention
National Heart
medicine.disease
Sudden
United States
cardiovascular diseases
Death
Sudden
Cardiac
Good Health and Well Being
Cardiovascular System & Hematology
National Heart
Lung
and Blood Institute (U.S.)
business
Zdroj: Circulation. Arrhythmia and electrophysiology, vol 14, iss 11
Circ Arrhythm Electrophysiol
ISSN: 1941-3084
1941-3149
DOI: 10.1161/circep.121.010190
Popis: Sudden cardiac death (SCD) is the sudden, unexpected death due to abrupt loss of heart function secondary to cardiovascular disease. In certain populations living with cardiovascular disease, SCD follows a distinct 24-hour pattern in occurrence, suggesting day/night rhythms in behavior, the environment, and endogenous circadian rhythms result in daily spans of increased vulnerability. The National Heart, Lung, and Blood Institute convened a workshop, Understanding Circadian Mechanisms of Sudden Cardiac Death to identify fundamental questions regarding the role of the circadian rhythms in SCD. Part 2 summarizes research gaps and opportunities in the areas of population and clinical research identified in the workshop. Established research supports a complex interaction between circadian rhythms and physiological responses that increase the risk for SCD. Moreover, these physiological responses themselves are influenced by several biological variables, including the type of cardiovascular disease, sex, age, and genetics, as well as environmental factors. The emergence of new noninvasive biotechnological tools that continuously measure key cardiovascular variables, as well as the identification of biomarkers to assess circadian rhythms, hold promise for generating large-scale human data sets that will delineate which subsets of individuals are most vulnerable to SCD. Additionally, these data will improve our understanding of how people who suffer from circadian disruptions develop cardiovascular diseases that increase the risk for SCD. Emerging strategies to identify new biomarkers that can quantify circadian health (eg, environmental, behavioral, and internal misalignment) may lead to new interventions and therapeutic targets to prevent the progression of cardiovascular diseases that cause SCD.
Databáze: OpenAIRE
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