Foveal thickness reduction after anti-vascular endothelial growth factor treatment in chronic diabetic macular edema
| Autor: | Rodrigo Jorge, Ingrid U. Scott, Andre Messias, Antonio Brunno Nepomuceno, Katharina Messias, Gabriel Willmann, Leticia Barroso |
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| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Visual acuity genetic structures Bevacizumab bevacizumab central subfield foveal thickness 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine lcsh:Ophthalmology Optical coherence tomography Clinical Research Foveal Ophthalmology medicine ranibizumab Macular edema macular edema optical coherence tomography diabetes medicine.diagnostic_test business.industry DOENÇAS RETINIANAS Diabetic retinopathy medicine.disease Fluorescein angiography eye diseases diabetic retinopathy lcsh:RE1-994 030221 ophthalmology & optometry sense organs Ranibizumab medicine.symptom business medicine.drug |
| Zdroj: | International Journal of Ophthalmology, Vol 10, Iss 5, Pp 760-764 (2017) Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 2227-4898 2222-3959 |
| DOI: | 10.18240/ijo.2017.05.17 |
| Popis: | AIM: To report foveal thickness reduction in eyes with resolution of macular edema and recovery of a foveal depression after one-year of anti-vascular endothelial growth factor (anti-VEGF) therapy for center-involving diabetic macular edema (DME). METHODS: Foveal thickness was assessed with optical coherence tomography to determine the central subfield foveal thickness (CSFT) and macular volume in 42 eyes with DME (CSFT>275 µm). Evaluations also included measurement of best-corrected visual acuity (BCVA), and were performed at baseline, and upon foveal depression recovery achieved after 12 monthly intravitreal injections of either 1.5 mg/0.06 mL bevacizumab (n=21) or 0.5 mg/0.05 mL ranibizumab (n=21). Data was compared to 42 eyes of normally sighted, non-diabetic, healthy individuals with similar age, gender and race distributions. RESULTS: Mean baseline BCVA was 0.59±0.04 and 0.32± 0.03 logMAR (P |
| Databáze: | OpenAIRE |
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