Practical Guidelines for Therapeutic Drug Monitoring of Anticancer Tyrosine Kinase Inhibitors: Focus on the Pharmacokinetic Targets
| Autor: | Huixin Yu, C.M. Nijenhuis, Neeltje Steeghs, Jan H.M. Schellens, Alwin D. R. Huitema, Jos H. Beijnen |
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| Rok vydání: | 2014 |
| Předmět: |
Pharmacology
medicine.diagnostic_test business.industry Sunitinib Antineoplastic Agents Imatinib Protein-Tyrosine Kinases respiratory tract diseases Pazopanib Pharmacotherapy Pharmacokinetics Therapeutic drug monitoring Neoplasms Humans Medicine Pharmacology (medical) Dosing Drug Monitoring business Protein Kinase Inhibitors Tyrosine kinase medicine.drug |
| Zdroj: | Clinical Pharmacokinetics. 53:305-325 |
| ISSN: | 1179-1926 0312-5963 |
| Popis: | There is accumulating evidence for potential benefits of therapeutic drug monitoring (TDM) in the treatment of cancer with tyrosine kinase inhibitors (TKIs). Relationships between exposure and response (efficacy/toxicity) have been established for several TKIs. For example, the pharmacokinetic targets for efficacy of imatinib, sunitinib and pazopanib have been defined as trough plasma concentrations (Ctrough) of >1,000, >50 and >20,000 ng/mL for selected indications, respectively. Dose adjustment based on pharmacokinetic targets could therefore increase response rates and duration. Furthermore, with appropriate target concentrations defined, excessive side effects in patients using the current fixed dosing strategy may be prevented. This review provides a practical guideline for TDM for the currently approved TKIs at 28 February 2013. The focus of this article is on the elaboration of exposure and response relationships of TKIs with proposed pharmacokinetic targets, mainly Ctrough, and further on the interpretation of the pharmacokinetic targets with recommendations for dose titrations. |
| Databáze: | OpenAIRE |
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