Distamycin: An inhibitor of DNA-dependent nucleic acid synthesis
| Autor: | Jürgen Obermeier, Werner E.G. Müller, Rudolf K. Zahn, Armin Maidhof |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Male
Cell Survival Uracil Nucleotides DNA polymerase Amidines Tritium Toxicology Rauscher Virus Cell Line Micrococcus Mice Structure-Activity Relationship chemistry.chemical_compound Adenosine Triphosphate Species Specificity Escherichia coli Animals Cytotoxic T cell Pyrroles Polymerase chemistry.chemical_classification biology Cell growth Fishes RNA RNA-Directed DNA Polymerase DNA DNA-Directed RNA Polymerases Templates Genetic General Medicine Spermatozoa Molecular biology Anti-Bacterial Agents Leukemia Lymphoid Enzyme chemistry Biochemistry DNA Nucleotidyltransferases Nucleic acid biology.protein Oligopeptides Cell Division |
| Zdroj: | Chemico-Biological Interactions. 8:183-192 |
| ISSN: | 0009-2797 |
| DOI: | 10.1016/0009-2797(74)90040-4 |
| Popis: | Summary Distamycin A (DST-A) strongly inhibits cell proliferation of mouse lymphoma cells. The unbalanced growth of the cells observed during the DST-A caused inhibition cannot be linked to a cytotoxic effect. The DST-A effect on cell proliferation may be quenched by incubation with native DNA, but not with RNA. The two DST derivatives DST/4 and DST/5 show a high degree of inhibition of cell proliferation. DST-A inhibits the 4 different DNA-dependent DNA polymerases as well as the 3 DNA-dependent RNA polymerases to the same high extent, while inhibition of the enzymatic RNA-mediated DNA and RNA synthesis amounts to only 1.5% of it. Kinetic studies have shown that enzymatic DNA-dependent nucleic acid synthesis is inhibited in a competitive way. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|