Antiphospholipid antibodies in patients with autoimmune blistering disease
| Autor: | Minoru Hasegawa, Makoto Inaoki, Masahide Yamazaki, Kazuhiko Takehara, Takeshi Echigo, Shinichi Sato |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Pemphigoid animal structures Cardiolipins Enzyme-Linked Immunosorbent Assay Dermatology Phosphatidylserines Autoimmune Diseases Blister immune system diseases Antiphospholipid syndrome Thromboembolism Pemphigoid Bullous medicine Beta 2-Glycoprotein I Humans skin and connective tissue diseases Pemphigus foliaceus Aged Aged 80 and over biology business.industry fungi Pemphigus vulgaris Middle Aged medicine.disease Pemphigus Immunoglobulin M beta 2-Glycoprotein I Immunoglobulin G Immunology biology.protein Antibodies Antiphospholipid Female Prothrombin Bullous pemphigoid business |
| Zdroj: | Journal of the American Academy of Dermatology. 57(3):397-400 |
| ISSN: | 0190-9622 |
| Popis: | 金沢大学医学部附属病院皮膚科 Objective: Our purpose was to determine the serum levels and frequency of antiphospholipid antibodies (aPLs) and confirm the clinical importance of these antibodies in patients with autoimmune blistering disease (ABD). Methods: IgG and IgM anticardiolipin antibodies (aCL), IgG anticardiolipin-β2 glycoprotein I complex antibody (aCL/β2GPI), and IgG antiphosphatidylserine-prothrombin complex antibody (aPS/PT) were examined with an enzyme-linked immunosorbent assay in 71 patients with ABD, including pemphigus vulgaris, pemphigus foliaceus, and bullous pemphigoid. Results: The prevalence of IgG aCL, IgM aCL, aCL/β2GPI, and IgG aPS/PT was positive for 22.4%, 9.1%, 9.9%, and 25.4% of the ABD patients, respectively, whereas these antibodies were not detected in any of the normal control subjects. Ten of 20 patients with ABD who were attending our hospital in 2004 tested positive for aPLs, and thromboembolism was detected in 7 of 10 patients with aPLs. Limitations: Follow-up studies, especially with a large patient group, will be needed to clarify the clinical relevance of aPLs in ABD. Conclusion: aPLs are frequently detected in patients with ABD. Careful examination and follow-up for thromboembolism may be necessary in ABD patients with aPLs. © 2007 American Academy of Dermatology, Inc. |
| Databáze: | OpenAIRE |
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