Carnosine: can understanding its actions on energy metabolism and protein homeostasis inform its therapeutic potential?
| Autor: | Stephane R. Gross, Alan R. Hipkiss, Stephanie P. Cartwright, Roslyn M. Bill, Clare Bromley |
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| Rok vydání: | 2013 |
| Předmět: |
Parkinson's disease
Chemistry(all) Proteolysis Carnosine Review Nephropathy 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Methylglyoxal medicine Mode of action Cancer 030304 developmental biology chemistry.chemical_classification 0303 health sciences Reactive oxygen species medicine.diagnostic_test Diabetes Reactive oxygen species (ROS) Energy metabolism General Chemistry medicine.disease Yeast 3. Good health Cell biology Proteostasis chemistry Biochemistry Parkinson’s disease Alzheimer’s disease 030217 neurology & neurosurgery |
| Zdroj: | Chemistry Central Journal |
| ISSN: | 1752-153X |
| DOI: | 10.1186/1752-153x-7-38 |
| Popis: | The dipeptide carnosine (β-alanyl-L-histidine) has contrasting but beneficial effects on cellular activity. It delays cellular senescence and rejuvenates cultured senescent mammalian cells. However, it also inhibits the growth of cultured tumour cells. Based on studies in several organisms, we speculate that carnosine exerts these apparently opposing actions by affecting energy metabolism and/or protein homeostasis (proteostasis). Specific effects on energy metabolism include the dipeptide's influence on cellular ATP concentrations. Carnosine's ability to reduce the formation of altered proteins (typically adducts of methylglyoxal) and enhance proteolysis of aberrant polypeptides is indicative of its influence on proteostasis. Furthermore these dual actions might provide a rationale for the use of carnosine in the treatment or prevention of diverse age-related conditions where energy metabolism or proteostasis are compromised. These include cancer, Alzheimer's disease, Parkinson's disease and the complications of type-2 diabetes (nephropathy, cataracts, stroke and pain), which might all benefit from knowledge of carnosine's mode of action on human cells. |
| Databáze: | OpenAIRE |
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