Association between Dietary Patterns and Atopic Dermatitis in Relation to GSTM1 and GSTT1 Polymorphisms in Young Children
| Autor: | Hyojung Hwang, Soo-Jong Hong, Se-Young Oh, Hyogin Ahn, Jayong Chung, Sung-Ok Kwon |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
GST gene Genotyping Techniques Physiology Body Mass Index Fatty Acids Monounsaturated Surveys and Questionnaires Genotype Micronutrients Child dietary patterns polymorphisms atopic dermatitis young children Glutathione Transferase Genetics Nutrition and Dietetics integumentary system Fatty Acids Atopic dermatitis Micronutrient Child Preschool Fatty Acids Unsaturated Female Dietary Proteins Child Nutritional Physiological Phenomena lcsh:Nutrition. Foods and food supply youngchildren Inverse Association lcsh:TX341-641 Biology Article Dermatitis Atopic medicine Dietary Carbohydrates Humans Association (psychology) Polymorphism Genetic Case-control study Reproducibility of Results medicine.disease Dietary Fats Confidence interval Diet Nutrition Assessment Case-Control Studies Energy Intake Body mass index Food Science |
| Zdroj: | Nutrients, Vol 7, Iss 11, Pp 9440-9452 (2015) NUTRIENTS(7): 11 Nutrients Nutrients; Volume 7; Issue 11; Pages: 9440-9452 |
| ISSN: | 2072-6643 |
| Popis: | Previous research suggests the association of glutathione S-transferase (GST) gene polymorphisms or diet, but no interactions between these factors in atopic dermatitis (AD). We conducted a community-based case-control study including 194 AD and 244 matched non-AD preschoolers. Glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) present/null genotypes were evaluated uisng a multiplex PCR method. We measured dietary intakes by a validated food frequency questionnaire and constructed three dietary patterns such as “traditional healthy”, “animal foods”, and “sweets” diets. In stratified analyses by GST genotypes, the “traditional healthy” diet and reduced AD showed association only in the GSTM1-present group (odd ratio (OR) 0.31, 95% confidence interval (CI) 0.13–0.75). A similar pattern of the association existed in the combined GSTM1/T1 genotype that indicated the inverse association between the “traditional healthy” diet and AD in the double GSTM1/T1-present genotype group (OR 0.24, 95% CI 0.06–0.93). Results from the multiplicative test analyses showed that the “traditional healthy” diet on reduced AD was significant or borderline significant in the GSTM1-present group (OR 0.71, 95% CI 0.54–0.92 vs. GSTM1-null group) or the GSTM1/T1 double present group (OR 0.63, 95% CI 0.39–1.03 vs. GSTM1/T1 double null group). These findings demonstrate that the present type of GSTM1 may increase susceptibility to the potential effect of the “traditional healthy” diet on AD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|