The normal squamocolumnar junction is circumferentially even and minimal irregularities are manifestations of gastroesophageal acid reflux
| Autor: | Mats Hall, Jörgen Wenner, Stefan Öberg |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Esophageal pH Monitoring Esophageal Disorder Gastroenterology Asymptomatic 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Prospective Studies Esophagus Sweden Metaplasia medicine.diagnostic_test business.industry Squamocolumnar Junction Reflux Middle Aged medicine.disease Esophageal Sphincter Upper Endoscopy medicine.anatomical_structure 030220 oncology & carcinogenesis Barrett's esophagus Case-Control Studies GERD Gastroesophageal Reflux 030211 gastroenterology & hepatology Female Esophagogastric Junction Esophagoscopy medicine.symptom business |
| Zdroj: | Scandinavian journal of gastroenterology. 52(3) |
| ISSN: | 1502-7708 |
| Popis: | The macroscopic appearance of the normal squamocolumnar junction (SCJ) is often described as serrated with short projections of columnar mucosa that extend into the esophagus. As studies of the normal SCJ are sparse, the aim of this study was to test the hypothesis that the normal SCJ is even and that irregularities are manifestations of acid reflux.Fifty asymptomatic subjects and 149 patients with symptoms suggestive of gastroesophageal reflux disease underwent endoscopy and 48-h pH monitoring with a pH electrode positioned immediately above the SCJ. The shape of the SCJ was assessed according to the Z-line appearance classification and correlated with clinical characteristics and the degree of esophageal acid exposure in the most distal esophagus.Even SCJs without irregularities were significantly more common in asymptomatic subjects compared with patients (50% versus 10%, p .001) and were never found in patients with erosive esophagitis. The median degree of distal esophageal acid exposure in individuals with an even SCJ was within normal limits. With increasing degree of irregularity of the SCJ, the frequency and duration of reflux episodes, the degree of distal esophageal acid exposure, and the prevalence of abnormal acid exposure increased progressively and significantly.The shape of the normal SCJ is even and also minimal irregularities are a consequence of acid reflux, likely due to the formation of small areas of metaplastic columnar mucosa. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|