Is there an interest for hair analysis in non-intentional pediatric cannabis intoxication?

Autor: C. Bréhin, Sophie Breinig, Souleiman El Balkhi, Lucas Ricco, Isabelle Claudet, Michel Lavit
Přispěvatelé: Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Toulouse [Toulouse], Institut de Recherche en Santé Digestive (IRSD ), Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Limoges, CCSD, Accord Elsevier, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)
Rok vydání: 2020
Předmět:
Zdroj: Forensic Science International
Forensic Science International, Elsevier, 2020, 313, pp.110377-. ⟨10.1016/j.forsciint.2020.110377⟩
Forensic Science International, 2020, 313, pp.110377-. ⟨10.1016/j.forsciint.2020.110377⟩
ISSN: 0379-0738
DOI: 10.1016/j.forsciint.2020.110377
Popis: International audience; Background and objectives: The incorporation of drugs in the hair of young children differs from that of adults and the metabolism of cannabis cannot be the same. Our primary objective was to analyze the distribution of the different cannabinoids in children's hair samples. The secondary objective was to correlate the intensity of toxic environmental exposure to cannabinoid metabolite levels.Methods: This was a prospective, single-center, observational pilot study of a pediatric cohort. Included subjects were all children less than 6 years of age admitted to a tertiary pediatric emergency unit for proven cannabis intoxication during the reference period. A hair strand was sampled within 12 h of emergency admission.Results: Forty-one pediatric patients were consecutively enrolled. Hair analysis showed that 34 children were positive for D9-THC (range 0.06-284.4 ng/mg); 41 % of them were also positive for THC-COOH (range 0.26-2.76 pg/mg). Depending on the D9-THC concentration (>1 ng/mg), 39 % of the children could be considered exposed to an intensely toxic environment. The rate of THC-COOH detection steadily increased from 2015 to 2018 (18 %, 40 %, 50 %, 58 % for each consecutive year). Children intensely exposed weighed less on admission (p = 0.02), had more comatose presentations (p = 0.02), and more previous social issues (75 % versus 12 %, OR 22.0, p = 0.0002).Conclusion: Hair testing in this context indirectly shows the intensity of children's toxic environmental exposure by the cannabinoid metabolite threshold. This was very helpful during the collegial examination of the toddlers' environment and led to a full investigation and to appropriate decisions concerning social measures. (C) 2020 Elsevier B.V. All rights reserved.
Databáze: OpenAIRE
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