Differentiating locally recurrent rectal cancer from scar tissue: Value of diffusion-weighted MRI
| Autor: | Philipp Manegold, Sergio Grosu, Tobias Baumann, Axel Gerstmair, A.-O. Schäfer, Mathias Langer |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Colorectal cancer medicine.medical_treatment Sensitivity and Specificity 030218 nuclear medicine & medical imaging Diagnosis Differential Cicatrix 03 medical and health sciences 0302 clinical medicine Region of interest medicine Humans Effective diffusion coefficient Radiology Nuclear Medicine and imaging Aged Retrospective Studies Aged 80 and over Chemotherapy medicine.diagnostic_test Receiver operating characteristic Rectal Neoplasms business.industry Magnetic resonance imaging General Medicine Middle Aged medicine.disease Diffusion Magnetic Resonance Imaging ROC Curve 030220 oncology & carcinogenesis Female Radiology Neoplasm Recurrence Local Nuclear medicine business Chemoradiotherapy Diffusion MRI |
| Zdroj: | European Journal of Radiology. 85:1265-1270 |
| ISSN: | 0720-048X |
| DOI: | 10.1016/j.ejrad.2016.04.006 |
| Popis: | Objectives To determine a cut-off apparent diffusion coefficient (ADC) value distinguishing local recurrence from scar tissue in patients with rectal cancer treated with complete surgical tumour removal. Methods 72 patients were retrospectively included. Patients underwent 1.5T MRI including multiplanar T2-weighted turbo-spin-echo sequences (TSE) and axial single-shot epi-diffusion-weighted sequences (EPSE). Two independent observers measured mean tumour and scar tissue ADCs by manually drawing regions of interest (ROIs). The t -test and ROC analysis were used for comparison and determining an optimal discrimination threshold. As reference standard histopathological results were used in 23 patients (32%) and clinical follow-up in 49 patients (68%). Results Recurrent rectal cancer was found in 30 patients (4 female, 26 male, median age 63.13 years) and treatment related changes such as scar tissue in 42 patients (11 female, 31 male, median age 63.67 years). The mean ADC value of tumour recurrence was 1.02×10 −3 mm 2 /s (0.63–1.44×10 −3 mm 2 /s) and of scar tissue 1.77×10 −3 mm 2 /s (1.11–2.41×10 −3 mm 2 /s) showing a statistically significant difference (p −3 mm 2 /s with a sensitivity, specificity, and accuracy of 93%, 91%, and 92% respectively. Conclusions Diffusion weighted MRI allows for the differentiation of tumour recurrence from scar tissue after surgical resection of rectal cancer. |
| Databáze: | OpenAIRE |
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